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| NT-3、NT-4和BDNF在面神经逆行转运的动力学比较 | |
| 引用本文： | 李云春,陈泽莲,王全林,梁正路,匡安仁,何刚,高炳庆,林代诚. NT-3、NT-4和BDNF在面神经逆行转运的动力学比较[J]. 四川大学学报(医学版), 2001, 32(4): 535-537 |
| 作者姓名： | 李云春 陈泽莲 王全林 梁正路 匡安仁 何刚 高炳庆 林代诚 |
| 作者单位： | 1. 华西医科大学附属第一医院核医学科,成都,610041 2. 华西医科大学附属第一医院药剂科 3. 华西医科大学附属第一医院耳鼻咽喉科 |
| 基金项目： | 高等学校博士学科点专项科研基金资助 (批准号 :96 0 6 30 15 ) |
| 摘 要： | 目的 研究神经营养素 3(NT- 3)、神经营养素 4(NT- 4)和脑源性神经营养因子 (BDNF)在面神经中的逆行转运动力学特点。方法 将新西兰兔一侧面神经干横切断后置入硅胶再生室 ,再将 1 2 5I标记的 NT- 3或NT- 4或 BDNF或人血清白蛋白 (HSA) (10μl/只 ,约 3.7MBq)注入再生室 ,在注药后于不同时刻取兔面神经干和脑干面神经运动核 ,测定其摄取率。利用 3P87动力学处理程序分析计算各标记物在面神经的动力学参数。结果 面神经逆行转运神经营养素的转运量 :NT- 3>BDNF>NT- 4(P <0 .0 5 ) ,转运速率 :NT- 4>NT- 3>BDNF (P <0 .0 5 )。结论 研究结果提供了神经营养素在面神经逆行转运的动力学特点。 |
| 关 键 词： | 神经营养素3 神经营养素4 脑源性神经营养素 逆行转运动力学 面神经 |
| 修稿时间： | 2000-03-23 |
A Comparison of the Kinetic Characters of NT-3, NT-4 and BDNF Retrogradely Transported in Facial Nerve |
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| Li Yunchun ,Chen Zelian,Wang Quanlin,Liang Zhenglu,Kuang Anren,He Gang,Gao Bingqing,Lin Daicheng. A Comparison of the Kinetic Characters of NT-3, NT-4 and BDNF Retrogradely Transported in Facial Nerve[J]. Journal of Sichuan University. Medical science edition, 2001, 32(4): 535-537 | |
| Authors: | Li Yunchun Chen Zelian Wang Quanlin Liang Zhenglu Kuang Anren He Gang Gao Bingqing Lin Daicheng |
| Affiliation: | Li Yunchun *,Chen Zelian,Wang Quanlin,Liang Zhenglu,Kuang Anren,He Gang,Gao Bingqing,Lin Daicheng. *Department of Nuclear Medicine,The First Affiliated Hospital,WCUMS,Chengdu,610041,China |
| Abstract: | Objective To compare the kinetic characters of retrograde transport of neurotrophin 3 (NT 3), neurotrophin 4 (NT 4) and brain derived neurotrophin factor (BDNF) in facial nerve. Methods Radioactive tracer technique was used. After one lateral facial nerve trunk of adult rabbit was transected, a silicone chamber was inserted between the stumps, and 3.7MBq of 125 I NT 3 or 125 I NT 4 or 125 I BDNF or 125 I HSA was administered into the chamber. At different time points after injection, the facial nerve trunk and facial nerve motor neurone of brain stem were collected and the uptake rates were measured. The kinetic parameters of each labeled compound were calculated using 3P87 program of kinetics. Results The transport amount of neurotrophin retrogradely transported by facial nerve is NT 3>BDNF>NT 4 ( P <0.05), the transport rate is NT 4>NT 3>BDNF ( P <0.05). Conclusion The findings could serve as the kinetic characters of retrograde transport of neurotrophins. [ |
| Keywords: | Neurotrophin 3 Neurotrophin 4 Brain derived neurotrophin factor Retrograde transport Kinetics Facial nerve |
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