Species barrier prevents an abnormal isoform of prion protein from accumulating in follicular dendritic cells of mice with Creutzfeldt-Jakob disease |
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| Authors: | T Muramoto T Kitamoto MZ Hoque J Tateishi I Goto |
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| Affiliation: | Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
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| Abstract: | The accumulation of abnormal prion protein in follicular dendritic cells did not occur in mice inoculated with materials from human Creutzfeldt-Jakob disease, whereas it always occurred in mice inoculated with mouse-adapted agents, suggesting an intense expression of the species barrier in the lymphoreticular system. |
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