小剂量红霉素预防早产儿喂养不耐受的临床研究

目的进行小剂量红霉素预防早产儿喂养不耐受的临床观察。方法符合入选条件的早产儿68例,随机分为预防治疗组(用药组)35例和对照组33例。治疗组采用静脉滴注10mg/(kg.min)的小剂量红霉素,连用7天。其他治疗措施两组相同。结果用药组28.57%(10/35)出现喂养不耐受,低于对照组的54.54%(18/33),差异有统计学意义(χ2=3.89,P0.05)。用药组达到完全经肠道喂养的时间、黄疸持续时间、住院时间、每天大便次数均有明显差异,33例对照组有5例出现胆汁淤积性黄疸,而用药组有2例出现,但差别无统计学意义(χ2=1.89,P0.05)。两组中各有2例发生NEC,均无心律失常的发生;用药组无一例出现肝功能损害。结论小剂量红霉素预防早产儿喂养不耐受是安全有效的。

Low-dose erythromycin in preventing preterm children the clinical observation of feeding intolerance.

Objective：To carry out low-dose erythromycin in preventing preterm child feeding intolerance in clinical observation.Methods：68 cases of premature children in line with the conditions selected were randomly divided into prevention and treatment group（treatment group） of 35 cases and the control group of 33 cases.The treatment group received intravenous infusion of 10mg /（kg·min） of low-dose erythromycin,used in conjunction for 7 days.Other treatment measures the same two groups.Results：The treatment group 28.57%（10/35） appears feeding intolerance,lower than the control group 54.54%（18/33）,the difference was statistically significant（χ2 = 3.89,P0.05）.Treatment group achieved full enteral feeding time,duration of jaundice,hospitalization time and daily stool frequency were significant differences in 33 cases of the control group,5 patients had cholestatic jaundice,while the treatment group occurred in 2 patients,but the difference no statistically significant（χ2 = 1.89,P 0.05）.Two cases from each groups occurred NEC,no arrhythmias occurred;there was no case of liver dysfunction.In medication.Conclusion：Low-dose erythromycin in prevention of feeding intolerance in premature children is safe and effective.