基于ICA的一氧化碳中毒迟发性脑病患者默认脑网络损伤研究

目的分析一氧化碳中毒迟发性脑病患者(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)静息状态下默认脑网络改变特征,探讨磁共振在一氧化碳中毒迟发性脑病患者的认知损伤评估应用及研究价值。材料与方法采集22例DEACMP患者和22例年龄、性别、受教育年限相匹配健康对照组的fMRI数据,应用独立成分分析(independent component,ICA)法分离静息态脑网络成分并进行统计学分析,首先用单样本t检验制作网络成分模板,再运用两独立样本双侧t检验进行组间功能网络内异常脑区的比较,采用24项汉密尔顿抑郁量表(24-item Hamilton Rating Scale for depression,HAMD-24)、汉密尔顿焦虑量表(Hamilton Anxiety Rating Scale,HAMA)、简易精神状态评价量表(Mini-mental State Examination,MMSE)等评估临床症状。结果通过DEACMP与健康对照组数据分析获得静息态默认脑网络模板,静息态默认脑网络功能连接分析结果显示双侧额上回、双侧楔叶及左侧顶叶角回功能连接增强。结论一氧化碳中毒迟发性脑病患者存在静息状态下默认脑网络异常,主要表现为功能连接的增强;DEACMP患者脑内可能存在一定的认知功能代偿。

Study of the default mode network in delayed encephalopathy after acute carbon monoxide poisoning using independent component analysis

Objective: To explore the characteristic of brain function damage in delayed encephalopathy after acute carbon monoxide poisoning(DEACMP) by using the technique of resting-state functional magnetic resonance imaging technology. Materials and Methods: Twenty-two DEACMP patients and 22 age-, gender-and education-matched healthy controls were studied with resting-state fMRI scan. Independent component analysis(ICA) was employed for the data analysis. One-sample t-test was performed to make the mask of networks components. And then two-sample t-test was performed to explore the difference between DEACMP patients and healthy controls in functional networks. The 24-item Hamilton Rating Scale for depression(HAMD-24), Hamilton Anxiety Rating Scale(HAMA) and Mini-mental State Examination(MMSE) were performed to assess the clinical symptoms. Results: The resting-state mask of default mode network(DMN) was obtained by data analysis in groups. It was found that the DMN functional connectivity in DEACMP patients was higher than that of healthy controls in frontal sup medial, precuneus and angular left. Conclusions: Patients with DEACMP has DMN abnormalities, mainly presenting increased functional connections. Certain cognitive function compensation might occur in those patients.