Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency |
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Authors: | Szilágyi A Nagy A Tamás P Vizer M Szabó I Losonczy H |
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Affiliation: | Department of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary. andras.szilagyi@aok.pte.hu |
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Abstract: | Inherited thrombophilias are associated with an increased risk of maternal thromboembolism and certain adverse pregnancy outcomes, including second- and third-trimester fetal loss, placental abruption, severe intrauterine growth restriction, and early-onset, severe preeclampsia. Pregnant patients with severe thrombophilias, especially antithrombinopathies are at very high risk for both thromboembolism and adverse pregnancy outcomes. A case of a patient with antithrombin deficiency is reported, who had two successful pregnancies after eight miscarriages. Our case shows that a combined treatment with antithrombin substitution and a prophylactic, body-weight-adjusted dose of low-molecular-weight heparin may be successful in preventing pregnancy loss and thromboembolism in antithrombin deficiency during pregnancy, although other complications, such as preeclampsia and intrauterine growth restriction cannot always be prevented. |
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