Seroprevalence and trends of transfusion transmissible infections among retrospective blood donors in Western Azerbaijan Regional Blood Transfusion Center,Iran: A ten-years evaluation |
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| Authors: | Behzad Emadi Mojtaba Ghahraman Rezaieh Mansour Sedighi |
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| Affiliation: | 1. Azarbaijan-Gharbi Regional Blood Transfusion Center, Urmia, Iran;2. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;1. Department of transfusion medicine, Evercare Hospital, Dhaka, Bangladesh;2. Department of transfusion medicine, ICMR- National institute of immunohematology, Mumbai, India;3. Hematology and Stem cell Transplant, Evercare Hospital, Dhaka, Bangladesh;1. Blood Center of Ribeirao Preto, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil;2. Hospital “Albert Einstein”, Sao Paulo, Sao Paulo, Brazil;3. Institute of Cancer Research, IPEC, Guarapuava, Parana, Brazil;4. Genome Sequencing Facility, International Research Center, AC Camargo, Sao Paulo, Sao Paulo, Brazil;5. Institute of Health Strategic Management of the Federal District-IGESF, Brasilia-Federal District, Brazil;1. Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India;2. Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, India;3. Department of Transfusion Medicine, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India;1. Dept. of Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India;2. Dept. of Clinical Hematology and Medical Oncology, Malabar Cancer Centre, Thalassery, Kerala, India;3. Dept. of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, India;1. Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;2. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;3. Institute of Hematology and Transfusion Medicine, Warsaw, Poland Indiry Gandhi str. 14, 02-776 Warsaw, Poland;4. Stem Cell Bank, Central Clinical Hospital Warsaw Medical University, Poland, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;5. Department of Pediatrics Oncology, Children’s Memorial Health Institute, Warsaw, Poland, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland |
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| Abstract: | Transfusion transmissible infections (TTIs) have been a public health challenge for the accessibility, quality and safety of blood transfusion. The present study aimed to consider the prevalence and the trends of hepatitis B virus (HBV), hepatitis C virus (HCV), Human T-cell leukemia virus type 1 (HTLV-1), human immunodeficiency virus (HIV) and syphilis across the ten years among retrospective blood donors. A retrospective investigation of blood donors’ data covering the period from 22 May 2009 to 22 May 2019 was done. Data was accumulated and analyzed from Blood Transfusion Center records, pertaining to all donors who were screened for various TTIs using respective immunological techniques. Out of the 682,171 screened donors in the 2009–2019 study period, 2470 (0.36 %) were infected with at least one infectious agent. The overall prevalence of HBV, HCV, HTLV-1, HIV and syphilis were 1700 (0.25 %), 184 (0.027 %), 335 (0.05 %), 4 (0.0.05 %) and 247 (0.036 %), respectively. The study showed male dominated donor pool (96.79 %) with higher prevalence (0.34 %) of TTIs compared to female donors (0.02 %) with 3.21 % population. Despite the low prevalence of TTIs in our study, HBV, HCV, syphilis and HIV have remained a big threat to safe blood transfusion in Iran. Strict adherence to selection criteria, algorithm of donor screening, use of highly sensitive and specific methods for detection of TTIs, regular consultation and health education programs, prevention and sanitization strategies to reduce the risk of TTIs are recommended to reduce the risk of TTIs and ensure the safety of blood transfusion for recipient. |
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| Keywords: | HBV HCV HIV HTLV-1 Syphilis |
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