| β丁香烯醇的药理研究 |
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| 引用本文： | 唐法娣 卡如濂. β丁香烯醇的药理研究[J]. 中国药理学通报, 1991, 7(2): 145-148 |
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| 作者姓名： | 唐法娣 卡如濂 |
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| 作者单位： | 浙江医科大学平喘药研究室 杭州310006(唐法娣，卞如濂，谢强敏)，浙江医科大学平喘药研究室 杭州310006(周汉良) |
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| 摘 要： | β丁香烯醇是艾叶油的平喘有效成分β丁香烯经胃-肠液转化后的化合物。它对豚鼠药物性哮喘具有保护作用,作用强而持久。对豚鼠离体气管平滑肌有直接松弛作用。能抑制致敏豚鼠肺组织SRS-A的释放和拮抗SRS-A作用,并有镇咳、祛痰作用。本品是一平喘作用强而持久的新平喘化合物。
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| 关 键 词： | β丁香烯醇 豚鼠气管平滑肌 平喘 抗过敏 |
PHARMACOLOG1C STUDIES ON β-CARYOPHYLLENE ALCOHOL |
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| Tang Fadi,Bian Ruian,Xie Qianmin,Zhou Hanliang. PHARMACOLOG1C STUDIES ON β-CARYOPHYLLENE ALCOHOL[J]. Chinese Pharmacological Bulletin, 1991, 7(2): 145-148 |
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| Authors: | Tang Fadi Bian Ruian Xie Qianmin Zhou Hanliang |
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| Abstract: | β-caryophyllene was one of the effective antiasthmatic principles of essential oil of Artemisia argyi, by way of structural modification to form β-caryophyllene alcohol. P-caryophyllene alcohol could protect acetylcholine and histamine-induced asthma in guinea pig, and the effect was longer than 4h. It had relaxant effect on isolated guinea pig tra.cheal smooth muscle prepareations, and the pD2 values was 4.36 + 0.37. The drug not only significantly inhibited antigen induced release of SRS-A in the lung fragments of sensitized guinea pig( ID50 23mg/L ), but also inhibited SRS-A induced contraction of the guinea pig ileum(ID50 18mg/L). In addition, P-caryophyllene alcohol had antitussive and expectora'at actions. These results show that p-caryophyllene alcohol is a new antiathmatic drug. |
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| Keywords: | ?caryophyllene alcohol Guinea pig tracheal smooth muscle Antiasthmatic effect Antianaphylactic effect |
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