甘草酸二铵治疗肝纤维化的动态观察

目的 :观察甘草酸二铵治疗肝纤维化的疗效。方法 :2 0 0例 男性 135例 ,女性 6 5例 ,年龄 (37±s 2 1)a]慢性肝炎病人分为A组 4 5例 ,B组 15 5例。A组用门冬氨酸钾镁 2 0mL ,B组用甘草酸二铵 30 0mg ,均加入 5 %葡萄糖注射液 5 0 0mL ,ivgtt ,qd ,连用 6wk后改为口服药治疗 8wk。观察肝功能、血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )及肝组织学变化。结果 :治疗 6wk时 ,B组的ALT复常率为 74 .2 % ,明显优于A组 (4 6 % ) ,P <0 .0 1。治疗结束后 ,B组的肝纤维化程度明显减轻 ,与A组相比 ,HA和PCⅢ水平明显降低。结论 :甘草酸二铵不但有良好的改善肝功能作用 ,还具有抗肝纤维化作用

Dynamic observation of antifibrotic effect of diammonium glycyrrhizinate

AIM: To observe the antifibrotic effect of diammonium glycyrrhizinate in patients with chronic hepatitis B infection. METHODS: Two hundred patients (M 135, F 65; age (37± s 21)a) were divided into A group (control group) forty five patients, B group (therapy group) one hundred and fifty five patients. Patients in A group were treated with potassium aspartate and magnesium aspartatse 20 mL for 14 wk. Diammonium glycyrrhizinate 300 mg in 5 % glucose injection 500 mL were given by iv, gtt, qd, for 6 wk and orally for 8 wk to patients in B group. The levels of serum alanine aminotransferase (ALT), hyaluronic acid (HA), procollagen type Ⅲ (PCⅢ) and the histological changes were investigated. RESULTS: Six weeks after therapy, the restoration rate of ALT to normal in B group was 74.2 % , it was significantly higher than that in A group ( 46 % ). At the end of therapy, histological assessment revealed a significant improvement in hepatic fibrosis, and the level of HA, PCⅢ were also decreased significantly. Discrimination between A and B group showed significant difference ( P < 0.05 ). CONCLUSION: Diammonium glycyrrhizinate not only has good effect on hepatic function, but also it can improve the hepatic fibrosis.