超声造影评价瑞舒伐他汀与阿托伐他汀对颈动脉斑块新生血管作用的比较

目的：使用超声造影比较瑞舒伐他汀与阿托伐他汀对颈动脉软斑块新生血管的治疗效果。方法：对颈动脉软斑块患者，分别服用瑞舒伐他汀10mg/d或阿托伐他汀20mg/d，治疗6个月，利用血脂检查、常规超声及超声造影进行治疗前后相关指标的评估。结果：入选斑块数共80例，瑞舒伐他汀组与阿托伐他汀组血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平均显著低于治疗前（P<0.05），瑞舒伐他汀组TC和LDL-C水平显著低于阿托伐他汀组（P<0.05），但两组间TG水平无显著差别（P>0.05）。瑞舒伐他汀组与阿托伐他汀组斑块积分、增强强度（EI）及时间-强度曲线下面积（AUC）均显著低于治疗前（P<0.05），瑞舒伐他汀组斑块积分、EI及AUC均显著低于阿托伐他汀组（P<0.05）。结论：瑞舒伐他汀及阿托伐他汀有确切降脂作用，均可有效减少颈动脉软斑块内的新生血管，且瑞舒伐他汀作用强于阿托伐他汀。

Comparison of Rosuvastatin and Atorvastatin in Treatment of Carotid Plaque Neovascularization by Contrast-Enhanced Ultrasound

OBJECTIVE: To compare the therapeutic effects of rosuvastatin and atorvastatin on neovascularization of carotid plaques using contrast-enhanced ultrasound. Methods: Patients with carotid artery soft plaques were treated with rosuvastatin 10 mg/d or atorvastatin 20 mg/d for 6 months. The level of serum lipid, routine ultrasound and contrast-enhanced ultrasound were used to evaluate therapeutic effects before and after treatment. Results: A total of 80 plaques were enrolled. The total cholesterol(TC), triglycerides(TG) and low-density lipoprotein cholesterol(LDL-C) levels in the rosuvastatin group and the atorvastatin group were significantly lower than those before treatment (P<0.05). The TC and LDL-C in the rosuvastatin group were significantly lower than those in astorvastatin group (P<0.05), but there was no significant difference in TG between the two groups (P> 0.05). The plaque score, enhanced intensity(EI) and area under the time-intensity curve(AUC) in the rosuvastatin group and the atorvastatin group were significantly lower than those before treatment (P<0.05). The plaque score, EI and AUC of rosuvastatin group were also significantly lower than those of atorvastatin group (P<0.05). Conclusion: Rosuvastatin and atorvastatin have definite lipid-lowering effect, and can effectively reduce the neovascularization in carotid plaques. And the effect of rosuvastatin is stronger than that of atorvastatin.