交联透明质酸凝胶薄膜的制备和性能表征

用己二酸二酰肼（ADH）对透明质酸（HA）进行化学修饰，研究不同交联程度HA．ADH的理化性质．用溶剂挥发法制备出HA—ADH薄膜．经差示扫描量热仪DSC分析得知，交联后产物的微观结构发生了明显改变．该薄膜在缓冲溶液中发生溶胀，有很强的吸水能力，扫描电镜SEM图显示溶胀的薄膜呈现高度多孔的网状结构．粘度法测定HA和HA-ADH的特性粘数[η]分别为14．69dL／g和20．21dL／g．改性后HA-ADH薄膜的溶解性比HA薄膜的溶解性能明显降低，可使得高聚物在体内的存留时间增长．

Preparation and Characterization of Cross-linked Hyaluronan Hydrogel Films

Hyaluronan （HA） was chemically modified with adipic dihydrazide （ADH）, and physicochemical properties of the different cross-linked density HA-ADH were studied. HA-ADH films were prepared with a solvent evaporation method. After cross-linking, differential scanning calorimetric analysis indicated that mierostmeture of the product was obviously altered. The dried film had strong ability of water uptake, and a highly porous network structure was detected by scanning electron mierograph, after the film swelled in buffer. Intrinsic viscosity [η] was measured with viscosity method, and [η] of HA and HA-ADH are 14.69 dL/g and 20.21 dL/g , respectively. There was a notable decrease in solubility of HA-ADH film, compared with HA film, which could prolong the reservation time of the polymer in vivo.