纤维蛋白原与结直肠癌患者预后的多因素分析

目的探讨纤维蛋白原（fibrinogen,FIB）与结直肠癌患者预后之间的关系。方法回顾分析213例结直肠癌患者临床资料,探讨FIB与结直肠癌患者临床病理特征及预后的关系。结果 FIB水平与TNM分期、淋巴结侵犯、远处转移相关（P〈0.05）;FIB、TNM分期、淋巴结侵犯、远处转移、分化程度及肿瘤大小是患者生存率的影响因素（均P〈0.05）,FIB、淋巴结侵犯及远处转移是影响结直肠癌患者预后的独立风险因素;未转移的111例患者中,术后有47例出现转移,转移患者的FIB水平为（3.81±0.79）g/L,高于未转移者（P〈0.05）;全组5年生存率为59.2%（126/213）,213例患者平均生存时间为（1551.72±153.48）d,与FIB水平呈显著负相关（r=-0.41,P〈0.05）。结论 FIB水平与结直肠癌患者TNM分期及淋巴结侵犯相关,FIB水平、淋巴结侵犯及远处转移影响结直肠癌患者预后。

An analysis of the correlation of fibrinogen to the prognosis for patients of colorectal cancer

Objective To recognize the correlation of fibrinogen to the prognosis for patients of colorectal cancer. Method The clinical data of 213 patients with colorectal cancer were reviewed in order to recognize the patterns of the correlation of fibrinogen level to the prognosis for patients with colorectal cancer. Findings The level of FIB was found to correlate to TNM staging,lymph node metastasis,distant metastasis（ P 0. 05）; single factor analysis showed： FIB,TNM stage, lymph node metastasis,distant metastasis,differentiation and tumor size are factors affecting the survival rate（ P 0. 05）; COX multiple factor analysis showed： FIB,lymph node invasion and metastasis were recognized as independent risk factors affecting the prognosis; patients,47 cases of the111 cases without metastasis were found to have postoperative metastasis, and the level of FIB reached3. 81 ± 0. 79 g / L,higher than that of the patients without postoperative metastasis. The difference was statistically significant（ P 0. 05）; The rate of 5-year prognosis was 77. 9%（ 166 /213）. The average length of survival time for the 213 patients was（ 1551. 72 ± 153. 48） days,which was negatively correlated with the level of FIB（ r =-0. 41,P 0. 05）. Conclusion Fibrinogen was found to correlate to TNM stage and involvement of lylnphnodes in colorectal cancer. Fibrinogen,involvement of lylnphnodes,and distant metastasis are the independence factors affecting the prognosis.