可切除性胰腺癌的新辅助治疗

胰腺癌是肿瘤治疗中的难题,外科手术切除是惟一存在潜在治愈可能的治疗方法,但只有少数病例能够进行手术切除,而且术后总体生存率很低。新辅助治疗逐渐被研究应用于胰腺癌,不仅有希望提高手术切除胰腺癌病例的生存期,而且有可能通过降低胰腺癌分期提高手术切除率。虽然已有研究证实新辅助化疗或放化疗对可切除胰腺癌的效果,但总体结果仍存在很大争议。

Neoadjuvant Therapy for Resectable Pancreatic Cancer

Pancreatic cancer is one of the great challenges to oncologic doctors. While surgical treatment is the only treatment that holds the potential of cure, a minority of patients can undergo resection and the overall survival rates remain low. Neoadjuvant therapy has been investigated in pancreatic cancer to in- crease survival time of resectable disease and to downstage locally advanced disease for resection. Several studies have tested the role of neoadjuvant chemotherapy or chemoradiation in resectable pancreatic cancer, but the results still have great controversy.