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Enantio-differentiating hydrogenation of prochiral ketones over modified nickel |
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| Authors: | Tsutomu Osaw Tadao Harada Akira Tai |
| Affiliation: | a Faculty of Science, Toyama University, Gofuku, Toyama930, Japan b Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga520-21, Japan c Faculty of Science, Himeji Institute of Technology, Kanaji, Kamigori, Hyogo 678-12, Japan |
| Abstract: | This article reviews the enantio-differentiating hydrogenation of prochiral ketones over a asymmetrically modified catalyst, focusing on the hydrogenation of simple prochiral alkanones. The parameters affecting catalytic activity and enantiodifferentiating ability are considerable in number, and each parameter should be optimized in order to attain a highperformance enantio-differentiating catalyst. Optimization of the parameters and the mode of enantio-differentiation are discussed and compared with the enantio-differentiating hydrogenation of β-ketoesters. |
| Keywords: | Alkanone Enantio-differentiation Heterogenous catalyst Hydrogenation Asymmetric modification |
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