| 正交试验优选乙肝宁颗粒的澄清工艺 |
| |
| 引用本文： | 颜红,夏新华,谢安,严建业,徐学云,朱丽,欧金秀,王艳平,熊飞燕.正交试验优选乙肝宁颗粒的澄清工艺[J].中国药房,2010(15):1364-1367. |
| |
| 作者姓名： | 颜红 夏新华 谢安 严建业 徐学云 朱丽 欧金秀 王艳平 熊飞燕 |
| |
| 作者单位： | 湖南中医药大学药学院;湖南九芝堂股份有限公司; |
| |
| 基金项目： | 国家科技攻关计划课题(2001BA701A48) |
| |
| 摘 要： | 目的:优选ZTC1+1-Ⅱ、ZTC1+1-Ⅲ澄清剂用于乙肝宁颗粒的纯化工艺。方法:采用正交试验法对影响絮凝效果的主要因素进行优选,并与醇沉工艺进行比较。结果:采用ZTC1+1-Ⅱ澄清工艺的芍药苷保留率高,且可改善干膏粉的吸湿性。其最佳澄澄清清工条艺件可为用药于液乙浓肝度宁1∶颗7,粒搅的拌纯速化度。350r.min-1,80℃加入B组分0.4mL.g-1,60℃再加入A组分0.2mL.g-1。结论:ZTC1+1-Ⅱ
|
| 关 键 词： | 乙肝宁颗粒 ZTC1+1-Ⅱ型澄清剂 ZTC1+1-Ⅲ型澄清剂 醇沉工艺 正交试验 |
Optimization of the Clarification Technology of Yiganning Granules by Orthogonal Experiment |
| |
| YAN Hong,XIA Xin-hua,YAN Jian-ye,WANG Yan-ping,XIONG Fei-yan XIE An,XU Xue-yun,ZHU Li,OU Jin-xiu.Optimization of the Clarification Technology of Yiganning Granules by Orthogonal Experiment[J].China Pharmacy,2010(15):1364-1367. |
| |
| Authors: | YAN Hong XIA Xin-hua YAN Jian-ye WANG Yan-ping XIONG Fei-yan XIE An XU Xue-yun ZHU Li OU Jin-xiu |
| |
| Affiliation: | YAN Hong,XIA Xin-hua,YAN Jian-ye,WANG Yan-ping,XIONG Fei-yan(School of Pharmacy,Hunan University of TCM,Changsha 410208,China) XIE An,XU Xue-yun,ZHU Li,OU Jin-xiu(Hunan Jiuzhitang Co.,Ltd.,Changsha 410008,China) |
| |
| Abstract: | OBJECTIVE：To optimize the clarification technology of Yiganning granules by ZTC1＋1-Ⅱand ZTC1＋1-Ⅲclearing agent.METHODS：Orthogonal experiment was applied to optimize the influence factors of flocculation effect and compared with alcohol precipitation technology. RESULTS：Retention rate of peoniflorin in ZTC1＋1-Ⅱclarification technology was high and improve the hygroscopicity of powder. The optimal conditions were as follows：extracting solution concentration was 1 ∶ 7,the whisking speed was 350 r·min-1;0.4 mL·g-1 B was added into solution at 80 ℃,then 0.2 mL·g-1 A was added into solution at 60 ℃. CONCLUSION：ZTC1＋1-Ⅱ clarification technology can be used to purify Yiganning granules. |
| |
| Keywords: | Yiganning granules ZTC1＋1-Ⅱ clearing agent ZTC1＋1-Ⅲ clearing agent Alcohol precipitation technology Orthogonal experiment |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
