| Effects of Aprotinin on Serum Interleukin-2 and Soluble Interleukin-2 Receptor during Cardiopulmonary Bypass |
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| 引用本文： | 罗军,汪东仿,蓝鸿钧,孙宗全. Effects of Aprotinin on Serum Interleukin-2 and Soluble Interleukin-2 Receptor during Cardiopulmonary Bypass[J]. 华中科技大学学报(医学英德文版), 2000, 20(2): 143-144. DOI: 10.1007/BF02887056 |
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| 作者姓名： | 罗军 汪东仿 蓝鸿钧 孙宗全 |
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| 作者单位： | Department of Heart Surgery，Institute of Cardiovascular Diseases，Tongji Medical University，Wuhan 430022 |
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| 基金项目： | a grant from the NationalNatural Science Foundation of China (No. 39270658). |
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| 摘 要： | Cardiopulmonary bypass (CPB) impairs immunedefense function. It has been documented by a lot ofresearch that interleukin--2 and its receptor are of importance in regulating immunity responses. We observed the changes of interleukin--2 (IL--2) and soluble interleukin--2 receptor (IL--ZR) during heart valve(s) replacement operation and effects of aprotinin onthem.1 MATERIALS AND METHODSTwenty patients undergoing heart valve (s) replacement were randomly divided into two groups:control…
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| 收稿时间： | 1999-12-15 |
Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass |
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| Luo Jun M. D., Ph.D.,Wang Dongfang,Lan Hongjun,Sun Zongquan. Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2000, 20(2): 143-144. DOI: 10.1007/BF02887056 |
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| Authors: | Luo Jun M. D. Ph.D. Wang Dongfang Lan Hongjun Sun Zongquan |
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| Affiliation: | (1) Department of Heart Surgery, Institute of Cardiovascular Diseases, Tongji Medical University, 430022 Wuhan |
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| Abstract: | Interleukin-2 and its receptor are of importance in regulating immunity responses. The changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (IL-2R) during heart valve (s) replacement operation and effects of aprotinin on them were observed. Twenty patients undergoing heart valve (s) replacement were randomly divided into two groups: control group (n=10) and apro- tinin group (n=10). In aprotinin group, 1 000 000 KIU aprotinin was given by vein injection and then 2 000 000 KIU was given as a bolus in prime. Blood samples were collected before CPB, right after CPB and on the 1st, 3rd and 7th postoperative day (POD) for serum IL-2 and sIL-2R determination. Results showed that after CPB, IL-2 was reduced and slL-2R increased. Meanwhile, serum IL-2R was lower in aprotinin group than that of control. It is concluded that the immunity depression after CPB is associated with low level of IL-2 and high level of sIL-2R and aprotinin can ameliorate the situation. |
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| Keywords: | cardiopulmonary bypass interleukin-2 soluble interleukin-2 receptor aprotinin |
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