| 通痹胶囊治疗类风湿关节炎（寒湿痹阻型）临床疗效及安全性观察 |
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| 引用本文： | 王晓磊,武晔,于笑霞,徐萍,平利峰,孙凤艳,胡丽伟.通痹胶囊治疗类风湿关节炎（寒湿痹阻型）临床疗效及安全性观察[J].天津中医药大学学报,2017,34(7):443-445. |
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| 作者姓名： | 王晓磊 武晔 于笑霞 徐萍 平利峰 孙凤艳 胡丽伟 |
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| 作者单位： | 河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000,河北省沧州中西医结合医院风湿免疫科, 沧州 061000 |
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| 基金项目： | 河北省中医药管理局项目（2017137） |
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| 摘 要： | 目的] 观察通痹胶囊治疗寒湿痹阻型类风湿关节炎的临床疗效及安全性。方法] 100例类风湿关节炎（寒湿痹阻型）的患者随机分为两组，每组50例。对照组口服来氟米特+甲氨蝶呤治疗；治疗组在对照组的基础上加用通痹胶囊。观察两组在治疗前后中医证候疗效、中医临床症状积分、美国风湿病学会评分（ACR 20、ACR50）、白介素-1（IL-1）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的变化，同时观察血常规、肝肾功能等安全性指标的变化以了解其临床应用安全性。 结果] 治疗组能明显降低中医临床症状积分（P<0.05），尤其在麻木、怕凉等症状改善尤为显着；治疗1 a后治疗组ACR20、ACR50分别为88%、74%，显着高于对照组66%、60%（P<0.05）；通痹胶囊能够更好降低IL-1、IL-6、TNF-α含量。两组在肝肾功能等安全性指标的比较中无明显差异。结论] 联合应用通痹胶囊及慢作用药改善怕凉、麻木等症状有较好的临床疗效及安全性。
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| 关 键 词： | 通痹胶囊 类风湿关节炎 寒湿痹阻型 临床疗效 安全性 |
| 收稿时间： | 2017/3/3 0:00:00 |
Observation of clinical curative effect and security of Tongbi capsule in treating rheumatoid arthritis (syndrome of cold-dampness blocking the channals and collaterals) |
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| WANG Xiao-lei,WU Ye,YU Xiao-xi,XU Ping,PING Li-feng,SUN Feng-yan and HU Li-wei.Observation of clinical curative effect and security of Tongbi capsule in treating rheumatoid arthritis (syndrome of cold-dampness blocking the channals and collaterals)[J].Journal of Tianjin University of Traditonal Chinese Medicine,2017,34(7):443-445. |
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| Authors: | WANG Xiao-lei WU Ye YU Xiao-xi XU Ping PING Li-feng SUN Feng-yan and HU Li-wei |
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| Affiliation: | Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China,Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China,Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China,Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China,Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China,Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China and Rheumatology and Immunology Department, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China |
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| Abstract: | |
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| Keywords: | Tongbi capsule rheumatoid arthritis syndrome of cold-dampness blocking the channals and collaterals clinical curative effect security |
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