Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion |
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| Authors: | Rudovsky Jakub Hermann Petr Botta Mauro Aime Silvio Lukes Ivan |
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| Affiliation: | Department of Inorganic Chemistry, Universita Karlova, Hlavova 2030, 128 40, Prague 2, Czech Republic. petrh@natur.cuni.cz |
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| Abstract: | A marked increase of relaxivity has been observed upon rigidifying the internal frame of Gd-containing PAMAM dendrimers: the effect has been attained by either protonation of the dendrimer or by forming supramolecular adducts with cationic polyaminoacids. |
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