阿立哌唑与利培酮治疗精神分裂症对照研究

目的:探讨阿立哌唑与利培酮治疗精神分裂症的疗效和不良反应。方法:应用阿立哌唑与利培酮分别治疗精神分裂症各34例,疗程8周。用阳性与阴性症状量表(PANSS)评定疗效,用治疗中出现的症状量表(TESS)评定药物不良反应。结果:两组PNSS总评分治疗前后差异有显著性。阿立哌唑组总有效率82.3%,利培酮组为82.3%,两者相同(P>0.05)。不良反应发生率:阿立哌唑组为19.82%,利培酮组为25.32%,阿立哌唑组低于利培酮组,差异有显著性(P<0.05)。结论:阿立哌唑与利培酮对精神分裂症有疗效好,且疗效相同。但不良反应少,是一种安全、有效的抗精神药。

Comparative study of schizophrenia treated with aripiprazole and risperidone

Objective:To study the effect and adverse reaction between aripiprazole and risperidone in the treatment of schizophrenia.Methods:Aripiprazole and risperidone were used respectively to treat schizophrenia in each 34 cases,for 8 weeks.The positive and negative symptoms scale(PANSS) was used to evaluate the clinical effect,while the treatment emergent symptoms scale(TESS) was used to evaluate the adverse reaction.Results:There was significant difference in the total score of PANSS in both groups before and after treatment.The total effective rate was 82.3% in aripiprazole group,and identical to that in risperidone group of 82.3%(P>0.05);while the incidenc rate of adverse reaction was 19.82% in aripiprazole group,lower than that in risperidone group of 25.32%,with significant difference between them(P<0.05).Conclusion:The results suggested that aripirazole was as effective in the treatment of schizophrenia as risperidone.But aripiprazole was a safe and effective antipsychotic drug,with less adverse reaction.