| 木糖醇与肾损害 |
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| 引用本文： | 沈丽津,孙丽荣. 木糖醇与肾损害[J]. 国际内分泌代谢杂志, 2007, 27(3): 187-189 |
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| 作者姓名： | 沈丽津 孙丽荣 |
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| 作者单位： | 300070,天津医科大学代谢病医院糖尿病痛风科;300070,天津医科大学代谢病医院糖尿病痛风科 |
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| 基金项目： | 天津市自然科学基金资助项目（07JCYBJC11400）. |
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| 摘 要： | 正常人体内,木糖醇为肝脏葡萄糖醛酸—木酮糖循环的糖代谢中间体,其浓度甚微,不会造成脏器损害。外源性木糖醇进入体内后经不同途径代谢成尿酸和草酸,二者均经肾脏排泄,故短时大量或长时间应用木糖醇可使血清尿酸、草酸水平骤然或缓慢升高,二者超出生理饱和度后均易形成结晶沉积到肾脏导致肾损害,甚而急性肾功能衰竭致死。
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| 关 键 词： | 木糖醇 尿酸 草酸 肾病 |
| 修稿时间： | 2006-05-08 |
Xylitol and renal damage |
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| SHEN Li-jin,SUN Li-rong. Xylitol and renal damage[J]. International JOurnal of Endocrinology and Metabolism, 2007, 27(3): 187-189 |
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| Authors: | SHEN Li-jin SUN Li-rong |
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| Affiliation: | Department of Diabetes and Gout, The Metabolic Disease Hospital, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | Xylitol is a normal intermediate in the liver glucuronate-xylulose cycle. When the level of plasma xylitol is very low, it would not hurt the organ. Exogenous xylitol is metabolized into uric acid and oxalic acid in the body through different pathways. Both of them are renal excretion. Accordingly, xylitol enter into the body either in short time or in long time could suddenly or slowly increase the level of uric acid and oxalic acid in plasma. When the concentrations exceed the physiological saturation, they could form amounts of crystals depositing in kidney and damage it or even cause acute renal failure ending in death. |
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| Keywords: | Xylitol Uric acid Oxalic acid Renal damage |
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