2种美罗培南治疗急性细菌性感染的对照研究

目的:观察国产与进口美罗培南治疗急性细菌性感染的有效性与安全性。方法:46例病人分为2 组,每组23例;试验组应用国产美罗培南,对照组应用进口美罗培南,均为每次给药1.0 g,静脉滴注,q 8 h, 疗程6-14 d。结果:进入疗效分析的病例数为45例,其中试验组22例,对照组23例,治疗结束2组的临床有效率分别为91％与91％;细菌清除率分别为80％与82％,2组不良反应发生率分别为4％与4％,均无显著差异(P>0．05)。结论:国产和进口美罗培南对治疗临床细菌性感染性疾病均有效、安全。

A comparative study of two kinds of meropenem in treatment of bacterial infections

AIM:To observe the efficacy and safety of domestic meropenem and imported one. METHODS: A controlled clinical study was conducted to compare the efficacy and safety of domestic meropenem with those of imported one. Forty-six patients were divided into domestic meropenem group and imported meropenem group,with 23 in each;under administration of 1 g every 8 h intravenously for each patient with corresponding domestic on imported meropenem for a course of 6 to 14 d respectively. RESULTS: Twenty-two patients in domestic meropenem group and twenty-three patients in imported meropenem group were assessable for clinical efficacy; outcoming with clinical efficacy rates 91 % vs 91 % , bacterial eradication rates 80 % vs 82 % and adverse reaction rates 4 % vs 4 % respectively. There was no statistically difference between the two groups (P > 0.05). CONCLUSION: Domestic meropenem is as effective and safe as imported meropenem in the treatment of bacterial infections.