| 卡氏肺孢子虫感染动物模型建立与电镜观察 |
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| 引用本文： | 张忠广,韩敏,常志尚,宫玉香.卡氏肺孢子虫感染动物模型建立与电镜观察[J].青岛大学医学院学报,2001,37(1):53-54,F002. |
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| 作者姓名： | 张忠广 韩敏 常志尚 宫玉香 |
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| 作者单位： | 青岛大学医学院寄生虫学教研室 |
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| 摘 要： | （1）目的 观察卡氏肺孢子虫及病变肺组织超微结构，探讨卡氏肺孢子虫的可能致病机制。（2）方法 肌注地塞米松诱发大鼠卡氏肺孢子虫肺炎，取其肺组织，按常规方法进行透射电镜观察。（3）结果 电镜下第22-28天即可观察到卡氏肺孢子虫的感染，以包囊为主；第43-56天达重度感染，以滋养体为主，肺泡腔内多见，肺间质中少见，中性粒细胞、肺泡巨噬细胞和Ⅱ型肺泡上皮细胞内也可见到。（4）结论 大滋养体伸出丝状伪足与Ⅰ，Ⅱ型肺泡上皮细胞粘连使上皮细胞发生变化。Ⅱ型上皮细胞发生凋亡。
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| 关 键 词： | 超微结构 大鼠 卡氏肺孢子出感染 动物模型 电镜 肺炎 |
| 文章编号： | 1001-4047(2001)01-0053-02 |
ESTABLISHMENT OF RAT MODEL OF PNEUMOCYSTIS CARINII AND ELECTRON-MICROSCOPIC OBSERVATIONS |
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| ZHANG Zhongguang,HAN Min,CHANG Zhishang,et al\.ESTABLISHMENT OF RAT MODEL OF PNEUMOCYSTIS CARINII AND ELECTRON-MICROSCOPIC OBSERVATIONS[J].Acta Academiae Medicinae Qingdao Universitatis,2001,37(1):53-54,F002. |
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| Authors: | ZHANG Zhongguang HAN Min CHANG Zhishang \ |
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| Affiliation: | ZHANG Zhongguang,HAN Min,CHANG Zhishang,et al\ Department of Parasitology,Qingdao University Medical College,Qingdao 266021 \, [ |
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| Abstract: | Objective To study the pathogenecity of pneumocystis carinii to the host by establishing a rat model. Methods The rats were injected intramuscularly with dexamethasone and sacrificed weekly to examine their lungs under an electron microscope. Results A large number of P.carinii were observed in alveolar space and a few in alveolar interstitium, they were also found in the neutrophil, pulmonary macrophage and typeⅡ alveolar epithelial cell. Conclusion The large trophozoites with filopodina were directly attached to the type Ⅰ and type Ⅱ pneumocyte then type Ⅰ and Ⅱ pneumocyte degenerated and apoptosis occurred. |
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| Keywords: | pneumocystis carinii ultrastructure rats |
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