Impact of Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein in Patients with Hepatitis C Virus-Related Compensated Liver Cirrhosis |
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| Authors: | Kunihiro Hasegawa Ryo Takata Hiroki Nishikawa Hirayuki Enomoto Akio Ishii Yoshinori Iwata Yuho Miyamoto Noriko Ishii Yukihisa Yuri Chikage Nakano Takashi Nishimura Kazunori Yoh Nobuhiro Aizawa Yoshiyuki Sakai Naoto Ikeda Tomoyuki Takashima Hiroko Iijima Shuhei Nishiguchi |
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| Affiliation: | Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo 663-8501, Japan; (K.H.); (R.T.); (H.N.); (A.I.); (Y.I.); (Y.M.); (N.I.); (Y.Y.); (C.N.); (T.N.); (K.Y.); (N.A.); (Y.S.); (N.I.); (T.T.); (H.I.); (S.N.) |
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| Abstract: | We aimed to examine the effect of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) level on survival comparing with other laboratory liver fibrosis markers in hepatitis C virus (HCV)-related compensated liver cirrhosis (LC) (n = 165). For assessing prognostic performance of continuous fibrosis markers, we adapted time-dependent receiver operating characteristics (ROC) curves for clinical outcome. In time-dependent ROC analysis, annual area under the ROCs (AUROCs) were plotted. We also calculated the total sum of AUROCs in all time-points (TAAT score) in each fibrosis marker. WFA+-M2BP value ranged from 0.66 cutoff index (COI) to 19.95 COI (median value, 5.29 COI). Using ROC analysis for survival, the optimal cutoff point for WFA+-M2BP was 6.15 COI (AUROC = 0.79348, sensitivity = 80.0%, specificity = 74.78%). The cumulative five-year survival rate in patients with WFA+-M2BP ≥ 6.15 COI (n = 69) was 43.99%, while that in patients with WFA+-M2BP < 6.15 COI (n = 96) was 88.40% (p < 0.0001). In the multivariate analysis, absence of hepatocellular carcinoma (p = 0.0008), WFA+-M2BP < 6.15 COI (p = 0.0132), achievement of sustained virological response (p < 0.0001) and des-γ-carboxy prothrombin < 41 mAU/mL (p = 0.0018) were significant favorable predictors linked to survival. In time-dependent ROC analysis in all cases, WFA+-M2BP had the highest TAAT score among liver fibrosis markers. In conclusion, WFA+-M2BP can be a useful predictor in HCV-related compensated LC. |
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| Keywords: | hepatitis C virus liver cirrhosis hepatocellular carcinoma Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) survival time-dependent receiver operating characteristics (ROC) analysis |
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