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TBAF-catalyzed synthesis of 5-substituted 1H-tetrazoles under solventless conditions |
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| Authors: | Amantini David Beleggia Romina Fringuelli Francesco Pizzo Ferdinando Vaccaro Luigi |
| Affiliation: | Dipartimento di Chimica, Laboratorio di Chimica Organica, Università di Perugia, CEMIN (Centro di Eccellenza Materiali Innovativi per applicazioni chimiche, fisiche e biomediche), via Elce di Sotto 8, I-06123 Perugia, Italy. |
| Abstract: | Tetrabutylammonium fluoride (TBAF) is an efficient catalyst in the 3 + 2] cycloaddition reaction of organic nitriles 1 with trimethylsilyl azide (TMSN(3)) in solventless conditions. The corresponding 5-substituted 1H-tetrazoles 2 were obtained under mild conditions and in 80-97% yields. |
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