小细胞肺癌干细胞信号通路的研究进展

小细胞肺癌是具有高度侵袭性的肺肿瘤，其主要临床特征是化疗有效率高但易在短时间内复发转移，这一特点可能与肿瘤干细胞的存在有关。肿瘤干细胞被认为是恶性肿瘤发生发展、耐药、复发及转移的根源。目前多认为肿瘤干细胞与正常干细胞有着相同的信号通路，如Hedgehog、Notch、Wnt等通路。本文就这几条信号通路在小细胞肺癌干细胞中所起的作用以及针对这几条信号通路治疗药物的研究进展和可能的信号通路交互作用等方面进行综述。

Signaling pathway of cancer stem cells in small cell lung cancer

Small cell lung cancer（SCLC） is a highly aggressive tumor and characterized by relapse and metastasis after highly effctive chemotherapy, which may be due at least in part to the existence of cancer stem cells （CSCs）. CSCs are known as the source of origin, progression, drug resistance, recurrence and metastasis in malignant tumors. CSCs use many of the same signaling pathways that are found in normal stem ceils, such as Hedgehog, Notch and Wnt. The role that embryonic signaling pathways plays in the function of CSCs in SCLC, the development of new anti-CSCs signaling pathways therapeutic agents, and the complexity of potential CSC signaling cross-talk are described in this review.