血清及腹水CA199、CA125水平在肝硬化患者中的临床意义

目的：探讨血清及腹水CA199、CA125水平在肝硬化患者中的临床意义。方法：肝硬化组91例，其中肝硬化无腹水患者50例，肝硬化伴腹水患者41例；正常对照组30例。检测血清CA199、CA125，肝硬化伴腹水患者同时检测血清及腹水CA199、CA125，并作相关性分析。结果：两组肝硬化患者血清CA199、CA125浓度均明显高于正常对照组。肝硬化伴腹水患者血清CA199、CA125水平显著高于肝硬化无腹水患者（P〈0．01）；血清CA199、CA125的水平随病情好转而下降。结论：肝硬化患者血清CA199、CA125升高水平与腹水的存在有关，作为肝硬化腹水的监测指标有一定的临床意义。

Role of CAl99,CAl25 levies of serum and ascites in liver cirrhosis

Objective:To investigate the clinical significance of CA199,CA125 levels of serum and ascites in hepatic cirrhosis.Methods:Ninety-one patients with liver cirrhosis were divided into two groups(group A,n=50;group B,n=41) according to existence of ascites and 30 health subjects were enrolled as control(group C),patients in group B with ascites underwent determination of CA199,CA125 levles of serum and ascites;patients in group A without ascites and group C underwent determination of CA199,CA125 levles of serum,and analysis of relation between CA199,CA125 and ascites was done.Results:Serum CA199,CA125 levels of patients in group B and A were significant higher than that in group C;serum CA199,CA125 levels of patients in group B were significant higher than that in group A(P<0.01);serum CA199,CA125 levels decreased with the improving of disease.Conclusion:Elevated serum CA199,CA125 levels of patients with cirrhosis relates to ascites,which may be a parameter for the monitoring of ascites.