卡尔曼滤波法同时测定复方氯唑沙宗片中2主药的含量

目的:建立以卡尔曼滤波法同时测定复方氯唑沙宗片中氯唑沙宗和对乙酰氨基酚含量的方法。方法:分别于248~296nm波长范围内每间隔1nm波长测定其吸收度,所得数据输入计算机,用卡尔曼滤波法程序进行分析。结果:氯唑沙宗、对乙酰氨基酚检测浓度的线性范围分别为2~20(r=0.9999)、3~30μg.mL-1(r=0.9997);平均回收率分别为99.1%(RSD=1.01%)、100.3%(RSD=0.92%)。结论:本方法简便、快捷、结果准确,可不经分离就同时测定该制剂中2主药的含量。

Simultaneous Determination of Chlorzoxazone and Paracetamol in Compound Chlorzoxazone Tablets by Kalman Filter Spectrophotometry

OBJECTIVE： To determine the contents of chlorzoxazone and paracetamol in compound chlorzoxazone tablets by Kalman Filter spectrophotometry. METHODS： The absorbabilities of the two components were detected in an interval of hnn over a wavelength range of 248-296 nm. The data obtained were computed by Kalman Filter program. RESULTS： Good linear relations were achieved when the concentration ranges of chlorzoxazone and paracetamol were 2-20μg·mL^-1 （ r = 0.9999） and 3-30μg·mL^-1（r =0.9997） respectively; the recovery rates were 99.1% （RSD =1.01%） and 100.3% （RSD = 0.92% ）, respectively. CONCLUSION： This method is simple, rapid and accurate, and it can be used for the simul-taneonsly determination of 2 components in compound chlorzoxazone tablets without separation.