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知母皂苷及其苷元的药理作用研究进展
引用本文:蔡飞,王维泓,高守红,陈万生. 知母皂苷及其苷元的药理作用研究进展[J]. 药学实践杂志, 2011, 29(5): 331-335
作者姓名:蔡飞  王维泓  高守红  陈万生
作者单位:1. 解放军广州军区机关门诊部药械科,广东广州,510080
2. 第二军医大学附属长征医院药学部,上海,200003
摘    要:知母皂苷及其苷元是临床常用中药材知母的最主要活性成分,具有广泛的生物活性和药理作用。研究表明,知母皂苷及其苷元具有防治老年痴呆症、保护脑缺血损伤、抗凝血、抗氧化、抗肿瘤、抗骨质疏松、抗炎、降血压、降血糖及降血脂等药理活性。本文对知母皂苷及其苷元的上述药理作用研究进展进行综述,为进一步开发利用提供参考。

关 键 词:知母皂苷  药理作用  研究进展
收稿时间:2011-04-12
修稿时间:2011-07-13

Advances in the pharmacological studies on timosaponins and their sapogenins
CAI Fei,WANG Wei-hong,GAO Shou-hong and CHEN Wan-sheng. Advances in the pharmacological studies on timosaponins and their sapogenins[J]. The Journal of Pharmaceutical Practice, 2011, 29(5): 331-335
Authors:CAI Fei  WANG Wei-hong  GAO Shou-hong  CHEN Wan-sheng
Affiliation:Department of pharmacy, Command outpatient department, Guangzhou Military District of PLA, Guangzhou 510080, China;Department of pharmacy, Command outpatient department, Guangzhou Military District of PLA, Guangzhou 510080, China;Department of pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;Department of pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Abstract:Timosaponins and their sapogenins were the major active components from a commonly used Chinese herbal medicine, Anemarrhenae Rhizoma. Studies showed that they had a broad range of pharmacological effects such as improving senile dementia, preventing cerebral ischemia, anti-coagulated blood, anti-oxidant, anti-tumor, anti-osteoporosis, anti-inflammation, lowering blood pressure, lowering blood sugar and lowering blood fat. Recent advances in the above biological activities were reviewed in this paper.
Keywords:timosaponin  pharmacological effects  advance
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