| 磺酰甘脲的合成工艺研究 |
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| 引用本文： | 朱超,桂艳,黄遥,周明善,陈晓春,朱丽,杨景成. 磺酰甘脲的合成工艺研究[J]. 化学试剂, 2021, 43(2): 253-255 |
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| 作者姓名： | 朱超 桂艳 黄遥 周明善 陈晓春 朱丽 杨景成 |
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| 作者单位： | 云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500;云南开放大学化学工程学院,云南昆明650500 |
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| 基金项目： | 云南省教育厅科学研究基金资助项目(2020J0490)。 |
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| 摘 要： | 为开发活性更强的甘脲类似物,进而扩大葫芦脲家族化合物的应用范围.以4,5-二羟基咪唑啉-2-酮、磺酰胺为原料合成了四氢-1H-咪唑并[4,5-c][1,2,5]噻二唑-5(3H)-酮-2,2-二氧化物(标题化合物),考察了不同反应条件对产物产率的影响.并通过'HNMRMS、IR对目标产物的结构进行了表征.研究表明,最佳...
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| 关 键 词： | 磺酰甘脲 合成 表征 葫芦脲 |
Synthesis Process of Sulfonyl Glycoluril |
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| ZHU Chao,GUI Yan,HUAGN Yao,ZHOU Ming-shan,CHEN Xiao-chun,ZHU Li,YANG Jing-cheng. Synthesis Process of Sulfonyl Glycoluril[J]. Chemical Reagents, 2021, 43(2): 253-255 |
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| Authors: | ZHU Chao GUI Yan HUAGN Yao ZHOU Ming-shan CHEN Xiao-chun ZHU Li YANG Jing-cheng |
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| Affiliation: | (School of Chemical Engineering,Yunnan Open University,Kunming 650500,China) |
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| Abstract: | In order to develop more active glycoluril analogs,and further expand the application range of cucurbituril family compounds,title compound tetrahydro-1H-imidazo[4,5-c][1,2,5]thiadiazol-5(3H)-one 2,2-dioxide was synthesized by the reaction of 4,5-dihydroxyimidazolin-2-one and sulfuric diamide,and optimized the reaction process conditions.The structure of the target product was confirmed by1HNMR,MS and IR.The optimal synthesis process was:the ratio of the amount of 4,5-dihydroxyimidazolin-2-one to sulfuric diamide was 1.1∶1,the pH was 5.5,the reaction temperature was 65℃,and the reaction time was 1.5 h.The yield was increased to 63.9%,which was nearly 10%higher than the literature data.It can provide an important basis for the further design and synthesis of cucurbituril analogs with sulfonylurea units. |
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| Keywords: | sulfonyl glycoluril synthesis characterization cucurbituril |
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