| 醋酸麦迪霉素干混悬剂溶出度测定方法的研究 |
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| 引用本文： | 李显林,尹翠娟,徐敬华,马立军,高书文.醋酸麦迪霉素干混悬剂溶出度测定方法的研究[J].中国药品标准,2004,5(4):44-46. |
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| 作者姓名： | 李显林 尹翠娟 徐敬华 马立军 高书文 |
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| 作者单位： | 沈阳第一制药厂药物研究所药物分析研究室,沈阳,110023 |
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| 摘 要： | 目的:研究测定醋酸麦迪霉素干混悬剂溶出度的方法.方法:采用桨法,以磷酸盐缓冲液(pH6.8)为溶剂,转速100r·min,紫外分光光度法232nm波长处测定吸收度.结果:30min的溶出量不少于标示量的70%,在0.08～0.4mg·ml-1范围内呈良好的线性关系,r=0.9993(n=5).结论:本方法准确可靠,能满足质量控制的要求.
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| 关 键 词： | 醋酸麦迪霉素干混悬剂 紫外分光光度法 含量测定 溶出度 |
Study on The Dissolution of Cusuan Maidimeisu Ganhunxuanji |
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| Authors: | Li Xianlin Yin Cuijuan Xu Jinghu Ma Lijun and Gao Shuwen |
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| Affiliation: | Department of pharmaceutical Analysts, Institute of Ma-tena Medica, Shenyang No.1 Pharmaceutical Factory, Shenyang, 110023;Department of pharmaceutical Analysts, Institute of Ma-tena Medica, Shenyang No.1 Pharmaceutical Factory, Shenyang, 110023;Department of pharmaceutical Analysts, Institute of Ma-tena Medica, Shenyang No.1 Pharmaceutical Factory, Shenyang, 110023;Department of pharmaceutical Analysts, Institute of Ma-tena Medica, Shenyang No.1 Pharmaceutical Factory, Shenyang, 110023;Department of pharmaceutical Analysts, Institute of Ma-tena Medica, Shenyang No.1 Pharmaceutical Factory, Shenyang, 110023 |
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| Abstract: | Objective: To study the dissolution of Cusuan Maidimeisu Ganhunxuanji.Methods: pHos-phato buffer solution (pH6.8) was used as the dissolution medium,the rotative velocity was 100r·min-1, ultraviolet spectrophotometry was used with a max absorption peak at the wave lengh of 232nm.Results: The standard curve was linear over the range of 0.08-0.4mg·ml-1,r=0.9993(n=5).Conclusion: The method was simple,accurate and reliable,It can be used for the assay of Cetirizine hydrochloride tablets. |
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| Keywords: | Cusuan Maidimeisu Ganhunxuanji Ultraviolet Spectrophotornetry Assaying Dissolution |
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