| 维生素D与ACE2在COVID-19中的作用 |
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| 引用本文： | 汤佳卫,孟祥哲,孙学敏,李玥轩,刘雪,魏红. 维生素D与ACE2在COVID-19中的作用[J]. 金属学报, 2022, 27(11): 1292-1298. DOI: 10.12092/j.issn.1009-2501.2022.11.012 |
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| 作者姓名： | 汤佳卫 孟祥哲 孙学敏 李玥轩 刘雪 魏红 |
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| 作者单位： | 济宁医学院基础医学院，济宁 272067，山东 |
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| 基金项目： | 国家自然科学基金资助项目（81902518）；山东省大学生创新创业训练计划项目（S202010443041）；济宁医学院大学生创新训练计划项目（cx2020082） |
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| 摘 要： | 新型冠状病毒肺炎（COVID-19）的蔓延，造成了巨大的人员伤亡和经济损失。血管紧张素转换酶2（ACE2）是严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）的受体，SARS-CoV-2附着在ACE2上，从而降低ACE2的表达并引起肺损伤。维生素D可以通过抑制ROCK通路活性，上调ACE2的表达和生物利用度，减缓AngⅡ积累引起的不良反应，抑制COVID-19的进展。本文探究了维生素D通过上调ACE2表达来保护机体抵抗COVID-19损伤的新颖机制，以期为维生素D防治COVID-19方面提供理论指导。
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| 关 键 词： | 血管紧张素转换酶2 维生素D SARS-CoV-2 COVID-19 |
| 收稿时间： | 2022-10-24 |
| 修稿时间： | 2022-12-02 |
Role of vitamin D and ACE2 in COVID-19 |
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| TANG Jiawei,MENG Xiangzhe,SUN Xuemin,LI Yuexuan,LIU Xue,WEI Hong. Role of vitamin D and ACE2 in COVID-19[J]. Acta Metallurgica Sinica, 2022, 27(11): 1292-1298. DOI: 10.12092/j.issn.1009-2501.2022.11.012 |
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| Authors: | TANG Jiawei MENG Xiangzhe SUN Xuemin LI Yuexuan LIU Xue WEI Hong |
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| Affiliation: | School of Basic Medicine Sciences, Jining Medical University, Jining 272067, Shandong, China |
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| Abstract: | The spread of COVID-19 has greatly threatened human health and economic growth. Angiotensin-converting enzyme 2 (ACE2) is a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). By attaching to ACE2, SARS-COV-2 reduces its expression and induces lung injury. Vitamin D can inhibit the progression of COVID-19 by inhibiting the activity of ROCK pathway, up-regulating ACE2 expression and bioavailability, and slowing down the adverse reactions caused by AngⅡ accumulation. This study explored a novel mechanism, i.e., vitamin D protects against COVID-19-induced injury by upregulating ACE2 expression. It provides theoretical guidance for the role of Vitamin D in the prevention and treatment of COVID-19. |
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| Keywords: | angiotensin-converting enzyme 2 vitamin D SARS-CoV-2 COVID-19 |
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