Novel synthesis and cytotoxic activity of some chromeno[3,4-<Emphasis Type="Italic">b</Emphasis>]pyrrol-4(3H)-ones |
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| Authors: | S S Soman T H Thaker R A Rajput |
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| Affiliation: | (1) Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India;(2) National Institute of Pharmaceutical Education and Research, Thaltej, Ahmedabad, India |
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| Abstract: | 1-Methylchromeno3,4-b]pyrrol-4(3H)-one and 1-phenylchromeno3,4-b]pyrrol-4(3H)-one derivatives have been synthesized by cyclization of amides obtained by condensing α-halo ketones with 3-amino-chromenones,
which show cytotoxic activity against lung, colon, and breast cancer cell lines. |
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