| 兰索拉唑中间体2-羟甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶的合成工艺研究 |
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| 引用本文： | 刘彪,廖健宇,周谧,李子成.兰索拉唑中间体2-羟甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶的合成工艺研究[J].四川化工,2007,10(2):1-3. |
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| 作者姓名： | 刘彪 廖健宇 周谧 李子成 |
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| 作者单位： | 四川大学化工学院制药与生物工程系,四川成都,610065 |
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| 摘 要： | 以2，3-二甲基吡啶为原料，经氧化、硝化、取代、酰化、水解得到2-羟甲基-3-甲基-4-（2，2，2-三氟乙氧基）吡啶。本文对文献报道的合成工艺进行了改进，提高了收率，简化了卮处理，节约了成本，更适合于工业生产。
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| 关 键 词： | 兰索拉唑 中间体 2-羟甲基-3甲基-4-(2 2 2-三氟乙氧基)吡啶 合成 |
The synthesis of the intermediate of Lansoprazole: 2-methylol-3-methyl-4-(2,2,2-trifluoethoxy) pyridine |
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| Liu Biao,Liao Jian-yu,Zhou Mi,Li Zi-cheng.The synthesis of the intermediate of Lansoprazole: 2-methylol-3-methyl-4-(2,2,2-trifluoethoxy) pyridine[J].sichuan chemical industry,2007,10(2):1-3. |
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| Authors: | Liu Biao Liao Jian-yu Zhou Mi Li Zi-cheng |
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| Affiliation: | Department of Pharmaceutical and biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu Sichuan 610065 |
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| Abstract: | The compound 2-methylol-3-methyl-4-(2,2,2-trifluoethoxy)pyridine was obtained starting from 2,3-lutidine ,via oxidation, nitration, substitution, acylation, hydrolization. In this paper, the synthetic route reported in literature was improved. As a result, the yield was raised, the aftertreatment was simplified and the cost was reduced. therefore, the process was more suitable for industrialization. |
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| Keywords: | Lansoprazole 2-methylol-3-methyl-4-(2 2 2-trifluoethoxy)pyridine synthesis |
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