| 半夏厚朴汤抗抑郁作用的研究—Ⅰ |
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| 引用本文： | 傅强 瞿融 等. 半夏厚朴汤抗抑郁作用的研究—Ⅰ[J]. 中国药科大学学报, 2002, 33(6): 514-517 |
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| 作者姓名： | 傅强 瞿融 等 |
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| 作者单位： | 1. 中国药科大学中药药理学教研室,南京,210038
2. 南京中医药大学,南京,210029 |
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| 摘 要： | 目的 研究半夏厚朴汤的抗抑郁作用。方法 采用小鼠强迫游泳，悬尾，育亨宾增强，高剂量阿扑吗啡拮抗等实验动物模型。评价半夏厚朴汤的抗抑郁作用。结果 半夏厚朴汤200，500mg/kg能显著缩短小鼠强迫游泳，悬尾不动时间，50，200，500mg/kg能增强育亨宾对小鼠的毒性作用。500mg/kg能拮抗阿扑吗啡降低小鼠体温作用。结论 半夏厚朴汤具有显著的抗抑郁作用。
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| 关 键 词： | 半夏厚朴汤 抗抑郁 动物模型 育亨宾 阿扑吗啡 拮抗 抑郁症 |
| 文章编号： | 1000-5048(2002)06-0514-04 |
| 修稿时间： | 2002-04-09 |
Antidepression Effect of Banxiahouputang Ⅰ. |
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| FU Qiang,MA Shi-Ping,QU Rong. Antidepression Effect of Banxiahouputang Ⅰ.[J]. Journal of China Pharmaceutical University, 2002, 33(6): 514-517 |
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| Authors: | FU Qiang MA Shi-Ping QU Rong |
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| Affiliation: | FU Qiang,MA Shi-Ping,QU Rong 1 Department of Pharmacology of the Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 210038, 1Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China |
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| Abstract: | AIM The purpose is to study the antidepressant effect of Banxiahouputang on animal models. METHODS The antidepressant effect of Banxiahouputang was evaluated through mice forced swimming test, mice tail suspension test,and antagonism of high dose of apomorphine and yohimbine potentiation model in mice. RESULTS Banxiahouputang significantly decreased the accumulative immobility time of mice treated with Banxiahouputang 200 and 500 mg/kg/day in mice forced swimming test and mice tail suspension test. Banxiahouputang significantly increased the death rate of mice treated with Banxiahouputang 50, 200 and 500 mg/kg/day in yohimbine potentiation model. Banxiahouputang significantly decreased the range of apomorphine-induced hypothermia in mice treated with Banxiahouputang 500 mg/kg/day. CONCLUSION Banxiahouputang had obvious effect of antidepression. |
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| Keywords: | Banxiahouputang Antidepressant Animal models Yohimbine Apomorphine |
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