| 维生素B6的合成工艺改进 |
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| 引用本文： | 范卫东,章根宝,徐勇智,党登峰,张晓增.维生素B6的合成工艺改进[J].广州化工,2012,40(17):46-47. |
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| 作者姓名： | 范卫东 章根宝 徐勇智 党登峰 张晓增 |
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| 作者单位： | 浙江天新药业有限公司,浙江台州,317200 |
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| 摘 要： | ＂噁唑法＂是目前工业上合成维生素B6的通用方法,本文对其关键步骤—芳构化进行改进,以2-正丙基-4,7-二氢-1,3-二氧七环、4-甲基-5-乙氧基噁唑为原料,经Diels-Alder、芳构化和水解三步反应制得维生素B6,总收率达81.6%。该工艺操作简单、能耗低,缩短了生产周期,适于工业化应用。
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| 关 键 词： | 维生素B6 Diels-Alder反应 芳构化 水解 |
Improved Preparation of Vitamin B6 |
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| FAN Wei-dong,ZHANG Gen-bao,XU Yong-zhi,DANG Deng-feng,ZHANG Xiao-zeng.Improved Preparation of Vitamin B6[J].GuangZhou Chemical Industry and Technology,2012,40(17):46-47. |
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| Authors: | FAN Wei-dong ZHANG Gen-bao XU Yong-zhi DANG Deng-feng ZHANG Xiao-zeng |
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| Affiliation: | (Zhejiang Tianxin Pharmaceutical Co.,Ltd.,Zhejiang Taizhou 317200,China) |
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| Abstract: | Oxazole was a general approach on the industrial synthesis of vitamin B6,and its key aromatization process was improred.With 4-methyl-5-oxyethyloxazole and 4,7-dihydro-2-propyl-1,3-dioxepin as raw materials,vitamin B6 was prepared by Diels-Alder reaction,aromatization and hydrolysis in 81.6% overall yield.This process had advantages of simple operation,low energy consumption,and shorter production cycles,so it was suitable for industrial application. |
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| Keywords: | vitamin B6 Diels- Alder reaction aromatization hydrolysis |
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