| 4-氟邻苯二酚的合成 |
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| 引用本文： | 徐浩,袁连山,李圣栋,凌勇.4-氟邻苯二酚的合成[J].陶瓷科学与艺术,2006(3). |
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| 作者姓名： | 徐浩 袁连山 李圣栋 凌勇 |
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| 作者单位： | 南京工业大学理学院 江苏南京210009 |
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| 基金项目： | 中化(青岛)横向课题374号 |
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| 摘 要： | 以对氟苯酚为原料,在浓硫酸催化下,经乙酸酐酯化反应生成乙酸对氟苯酯;乙酸对氟苯酯在三氯化铝作用下,发生Fries重排反应,生成5氟2羟基苯乙酮;再经Dak in氧化合成了4氟邻苯二酚。此路线总收率为45.4%,且产品及其中间体经IR1、H NMR和MS等谱图确证。整个路线,原料易得,条件温和,产率较高,适合于以后的进一步工业化生产研究。
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| 关 键 词： | 乙酸对氟苯酯 5-氟-2-羟基苯乙酮 4-氟邻苯二酚 Dakin氧化 |
Synthesis of 4-Fluorocatechol |
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| XU Hao,YUAN Lian-shan,LI Sheng-dong,LING Yong.Synthesis of 4-Fluorocatechol[J].Ceramics Science & Art,2006(3). |
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| Authors: | XU Hao YUAN Lian-shan LI Sheng-dong LING Yong |
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| Abstract: | 4-Fluorocatechol is an important intermediate for medicine.It is also a key precursor in the synthesis of fluorocatecholamines which have pharmaceutical activities.In this paper,4-fluorocatechol was synthesized by the esterification of 4-fluorophenol with acetic anhydride under the catalysis of concentrated sulfuric acid,rearrangement of 4-fluorophenyl acetate with anhydrous aluminum chloride,and Dakin oxidation of 5-Fluoro-2-hydroxyacetophenone.Its overall yield was 45.4%.The structures of 4-fluorocatechol and its intermediates were determinated by IR,H~(1)NMR and MS. |
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| Keywords: | 4-Fluorocatechol 5-Fluoro-2-hydroxyaceto-phenone 4-Fluorophenyl acetate Dakin oxidation |
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