| 2-羟基-3-氰甲基-5-甲基苯乙酮的合成 |
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| 引用本文： | 李敬芬,李彬,孙志忠. 2-羟基-3-氰甲基-5-甲基苯乙酮的合成[J]. 化学世界, 2002, 43(10): 537-539 |
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| 作者姓名： | 李敬芬 李彬 孙志忠 |
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| 作者单位： | 1. 佳木斯大学化学与药学院,黑龙江,佳木斯,154007
2. 黑龙江大学化学化工学院,黑龙江,哈尔滨,154000 |
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| 摘 要： | 探索黄酮醋酸类化合物中间体的合成方法。通过酰基化、Fries重排、氯甲基化和氰化合成2 -羟基 - 3-氰甲基 - 5 -甲基苯乙酮 ,获得了满意的收率 ( 88.5 % )。采用新方法合成了鲜见文献报道的新化合物 2 -羟基 - 3-氰甲基 - 5 -甲基苯乙酮。该方法具有反应时间短、操作简便、收率好等优点。
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| 关 键 词： | 对甲基苯酚 2-羟基-3-氰甲基-5-甲基苯乙酮 合成 |
| 文章编号： | 0367-6358(2002)10-0537-03 |
Synthesis of 2-Hydroxy-3-cyanomethyl-5-methyl-acetophenone |
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| LI Jing fen ,LI Bin ,SUN Zhi zhong. Synthesis of 2-Hydroxy-3-cyanomethyl-5-methyl-acetophenone[J]. Chemical World, 2002, 43(10): 537-539 |
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| Authors: | LI Jing fen LI Bin SUN Zhi zhong |
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| Affiliation: | LI Jing fen 1,LI Bin 1,SUN Zhi zhong 2 |
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| Abstract: | The synthetic methods of intermediate products of substituted flavone 8 acetic acids were studied. The synthesis was accomplished via acylation, Fries rearrangement reaction, chloromethylation and cyanation, and a good yield (88.5%) was obtained. Using the new method, 2 hydroxy 3 cyanmethyl 5 methyl acetophenone was synthesized in a short reaction period, and the yield was good. |
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| Keywords: | p methylphenol 2 hydroxy 3 cyanomethyl 5 methyl acetophenone synthesis |
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