"Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists" |
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| Authors: | J L Boyer C Cárdenas C Posadas J A García-Sáinz |
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| Affiliation: | 1. Departamnto de Endocrinología, Instituto Nacional de Cardiología “Ignacio Chávez”, Mexico;2. Departamento de Bioenergética, Centro de Investigaciones en Fisiología Celular, Universidad Nacional Autónoma de México. Apartado Postal 70-600, 04510, México, D.F. |
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| Abstract: | Administration of purified pertussis toxin to rats induced persistent tachycardia, (observed in conscious rats but not after pithing); as little as 0.05 microgram/100 g produced a significant effect. Pertussis toxin-treatment did not affected the pressor response produced in the pithed rats by the alpha 2-adrenergic agonist methoxamine but markedly diminished the pressor effect of the alpha 2-adrenergic agonists clonidine and azepexole. A role of adenylate cyclase inhibition in the action of postsynaptic vascular alpha 2-adrenergic receptors is suggested. |
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| Keywords: | To whom correspondence should be addressed. |
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