良性阵发性位置性眩晕87例发病危险因素研究

目的 探索原发性良性阵发性位置性眩晕（BPPV）发病危险因素。方法 选取于徐州医科大学附属医院住院并确诊BPPV病人87例为研究组，选择同期于该院体检健康者51例为对照组。收集两组间一般资料、既往病史、颈部超声、血脂分析及头颅CT等指标，采用散射比浊分析仪测定脂蛋白磷脂酶A2(Lp-PLA2)。结果 研究组颈部斑块检出率为44.83%(39/87)，高于对照组19.61%(10/51)(P<0.05)。研究组Lp-PLA2水平平均秩次76.02，比对照组58.38高（P<0.05）。研究组高血压、高脂血症、腔隙性脑梗死病史检出率分别为16.10%(14/87)、41.38%(36/87)、63.22%(55/87)，分别高出对照组3.92%(2/51)、8.05%(7/51)、39.22%(20/51)(P<0.05)；进行单因素分析筛选相关性较强的因素（P<0.05），纳入多因素logistic回归分析提示合并腔隙性脑梗死（OR=3.13）、颈部斑块（OR=3.63）、高脂血症（OR=4.40）及Lp-PLA2水平（OR=1.97）是原发性BPPV发病的独立危...

Study of risk factors for the development of benign paroxysmal positional vertigo in 87 cases

Objective To explore the risk factors for the development of benign paroxysmal positional vertigo (BPPV).Methods A total of 87 patients hospitalized at the Affiliated Hospital of Xuzhou Medical University with confirmed BPPV were selected as thestudy group, and 51 healthy individuals who were examined at the hospital during the same period were selected as the control group.General information, past medical history, neck ultrasound, blood lipid analysis and head CT were collected between the two groups,and lipoprotein-associated phospholipase A2 (Lp-PLA2) was measured by a scattering turbidimetric analyzer.Results The detection rate of neck plaque in the study group was 44.83% (39/87), which was higher than that of 19.61% (10/51) in the control group (P<0.05). The mean rank of Lp-PLA2 level was 76.02 in the study group, which was higher than that of 58.38 in the control group (P<0.05). Thedetection rates of hypertension, hyperlipidemia, and history of lacunar cerebral infarction in the study group were 16.10% (14/87),41.38% (36/87), 63.22% (55/87), respectively, which were higher than those of the control group (3.92% (2/51), 8.05% (7/51), and39.22% (20/51), respectively) (P<0.05). Single-factor analysis was performed to screen for strong correlations (P<0.05), and inclusion of multivariate logistic regression analysis suggested that the combination of lacunar cerebral infarction (OR=3.13), neck plaque (OR=3.63), hyperlipidemia (OR=4.40) and Lp-PLA2 level (OR=1.97) were independent risk factors for the development of primary BPPV (P< 0.05, OR>1).Conclusion Lacunar cerebral infarction, neck plaque, hyperlipidemia and Lp-PLA2 levels are independent risk factors for the development of primary BPPV.