慢性阻塞性肺疾病合并焦虑抑郁症的临床特征及相关危险因素分析

目的:分析住院慢性阻塞性肺疾病(COPD)患者合并焦虑抑郁症的临床特征及相关危险因素。方法:选取2019年1月至10月武汉大学人民医院呼吸与危重症医学二科153例COPD患者作为研究对象进行横断面研究，根据医院焦虑抑郁量表评分和肺功能结果分为单纯COPD组和COPD合并焦虑抑郁症组，比较2组临床特征，采用单因素和多因素...

Analysis of clinical characteristics and related risk factors of anxiety and depression in patients with chronic obstructive pulmonary disease

Objective To analyze the clinical characteristics and related risk factors of inpatients with chronic obstructive pulmonary disease(COPD)with anxiety and depression.Methods From January 2019 to October 2019,a total of 153 patients with COPD in the Second Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,were selected as the object of cross-sectional study,and according to the score of hospital anxiety and depression scale and the results of pulmonary function,they were divided into the group with simple COPD and the group with COPD combined with anxiety and depression.The clinical characteristics of the two groups were compared.The risk factors related to COPD with anxiety and depression were analyzed using single factor and multifactor logistic regression.Results(1)Sixty-one cases(39.9%)of COPD combined with anxiety and depression group.Thirty-eight cases(28.4%)with combined anxiety,fifty-five cases(35.9%)with combined depression.Thirty-two cases(20.9%)with anxiety and depression.(2)In the COPD group with anxiety and depression group,there was a higher proportion of acute exacerbation of COPD in the past year,a higher proportion of combined severe COPD,a higher modified Medical Research Council(mMRC)score,a higher COPD assessment test(CAT)score,and a longer course of disease,while forced vital capacity percent predicted,forced expiratory volume in the first second(FEV1)and FEV1 in percent predicted values(FEV1%pred)were lower,and the differences were statistically significant(all P<0.05).(3)Taking COPD combined with anxiety and depression as the dependent variables,body mass index(BMI),course of disease,acute exacerbation of COPD in the past year,FEV1%pred,severe COPD,arterial partial pressure of carbon dioxide(PaCO₂),mMRC score,CAT score as independent variables,respectively single factor logistic regression was performed,and the results showed that all the above variables were related to COPD complicated with anxiety and depression(all P<0.05).(4)Binary logistic regression analysis of the disease course,acute exacerbation of COPD in the past year,severe COPD,PaCO₂,age and BMI,respectively,the results showed that they were all independent risk factors for COPD complicated with anxiety and depression(P<0.05).The course of disease,acute exacerbation of COPD in the past year,severe COPD,PaCO₂,age,and BMI were simultaneously included in the binary logistic regression equation.The results showed that acute exacerbation of COPD in the past year was due to COPD complicated with anxiety and depression independent risk factors.Conclusions The prevalence of COPD patients with anxiety and depression is relatively high.Acute exacerbation of COPD have been more frequent in the past year,the proportion of patients with severe COPD is higher,the disease course is longer,the mMRC score and CAT score are higher.Acute exacerbation of COPD in the past year is an independent risk factor for COPD complicated with anxiety and depression.