| p16基因与肺癌关系研究进展 |
| |
| 引用本文： | 肖平,陈建荣.p16基因与肺癌关系研究进展[J].国际肿瘤学杂志,2010,37(11). |
| |
| 作者姓名： | 肖平 陈建荣 |
| |
| 作者单位： | 南通大学第二附属医院呼吸科,226001 |
| |
| 基金项目： | 江苏省"六大人才高峰"资助课题，南通市科委社会发展计划项目 |
| |
| 摘 要： | 肿瘤抑癌基因p16对于肺癌的早期诊断非常重要,启动子的异常甲基化、第二号外显子的纯合子缺失、基因点突变、蛋白及mRNA的缺失表达都与肺癌的发生关系密切,且与肺癌的基因治疗、药物靶向治疗有关.
|
| 关 键 词： | 基因 p16 肺肿瘤 甲基化 基因疗法 |
Progress of research on relationship between gene p16 and lung cancer |
| |
| XIAO Ping,CHEN Jian-rong.Progress of research on relationship between gene p16 and lung cancer[J].Journal of International Oncology,2010,37(11). |
| |
| Authors: | XIAO Ping CHEN Jian-rong |
| |
| Abstract: | p16 tumor suppressor gene plays an important role in early diagnosis for lung cancer. The occurrence of lung cancer is closed associated with p16 gene aberrant methylation in promotor, seconed exon homozygous deletion, gene point mutation , lose of protein and mRNA expression. Also p16 is related to gene therapy and drug target therapy. This review will summarize the relationship between p16 and lung cancer. |
| |
| Keywords: | Genes p16 Lung neoplasms Mythlation Gene therapy |
| 本文献已被 万方数据 等数据库收录！ |
|
