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| 微生物发酵法中试生产1,3-丙二醇 | |
| 引用本文： | 刘海军,张代佳,徐友海,孙亚琴,吕继萍,牟英,修志龙. 微生物发酵法中试生产1,3-丙二醇[J]. 现代化工, 2007, 27(2): 56-58 |
| 作者姓名： | 刘海军 张代佳 徐友海 孙亚琴 吕继萍 牟英 修志龙 |
| 作者单位： | 1. 大连理工大学生物科学与工程系,辽宁,大连116024;中国石油吉林石化分公司研究院,吉林,吉林132021 2. 大连理工大学生物科学与工程系,辽宁,大连116024 3. 中国石油吉林石化分公司研究院,吉林,吉林132021 |
| 基金项目： | 国家科技攻关计划;国家重点基础研究发展计划(973计划) |
| 摘 要： | 以甘油为原料,利用克雷伯氏菌进行了发酵罐容积规模分别为1 m3和20 m3的发酵法1,3-丙二醇生产的中试研究。试验结果表明:1m3和20m3的发酵罐最终发酵液中1,3-丙二醇平均质量浓度分别达到了74.6 g/L和63.9 g/L,1,3-丙二醇相对于甘油的得率分别为61.2%和49.9%。采用发酵液醇沉预处理、再精馏的专利技术可分离得到纯度大于99%的1,3-丙二醇产品,分离收率大于85%,产品质量达到了聚对苯二甲酸丙二酯(PTT)聚合反应的要求。成本分析表明,生物法生产1,3-丙二醇技术是经济可行的。 |
| 关 键 词： | 1,3-丙二醇 克雷伯氏菌 甘油 微生物发酵 中试 |
| 文章编号： | 0253-4320(2007)02-0056-03 |
| 修稿时间： | 2006-09-26 |
Production of 1,3-propanediol by microbiological fermentation on a pilot scale |
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| LIU Hai-jun,ZHANG Dai-jia,XU You-hai,SUN Ya-qin,LU Ji-ping,MU Ying,XIU Zhi-long. Production of 1,3-propanediol by microbiological fermentation on a pilot scale[J]. Modern Chemical Industry, 2007, 27(2): 56-58 | |
| Authors: | LIU Hai-jun ZHANG Dai-jia XU You-hai SUN Ya-qin LU Ji-ping MU Ying XIU Zhi-long |
| Abstract: | Fermentative production of 1,3-propanediol from glycerol by Klebsiella pneumoniae has been conducted up to the scale of 1 m3 and 20 m3.The experimental results showed that the final mass concentration,molar yield of 1,3-propanediol to glycerol were 74.6 g/L and 61.2% in 1 m3 reactor,63.9 g/L and 49.9% in 20 m3 reactor,respectively.By using ethanol precipitative pretreatment and rectification patent technology,the product 1,3-propanediol with purity of 99% had been harvested,the seperation yield of 1,3-propanediol was greater than 85%,and the product quality had met the polymerization standard.The cost analysis demonstrated that the microbial production of 1,3-propanediol was economically feasible. |
| Keywords: | 1 3-propanediol Klebsiella pneumoniae glycerol microbiological fermention pilot scale |
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