力生长因子与成骨细胞

骨组织对所处的力学环境有极强的适应能力.力学因素及非力学因素共同参与调节骨组织的生长、发育与适应性变化,但是关于两者之间的关联调控目前知之甚少.在骨骼肌肉系统中,IGF-I是一种与力刺激密切相关的骨生长因子.在力刺激作用下,IGF-I的pre-mRNA能选择性的剪接成为力生长因子（Mechano-growth factor,MGF）,MGF具有促进成肌干细胞和成骨细胞增殖,并抑制其终末分化的作用.在力刺激下,MGF参与骨骼肌肉的重建和修复过程.目前初步研究显示MGF主要分布在细胞核,其信号传导不通过IGF-IR介导.但关于MGF的细胞受体,作用靶点、作用机制和信号传导还未得到有效阐明;本文就MGF与骨骼的力学调控之间的关系进行综述.

Mechano Growth Factor and Osteoblasts

Bone has potential adaptive capacity to different mechanical stimulation. The growth, development and adaption of bone were regulated by mechanical factors and nonmechanial factors, but the correlative regulation was poorly understood. IGF is a growth factor which is tightly related with mechanical stimulation in skeletalmuscle system. Pre- mRNA of IGF-I can be alternatively spiliced into mechano-growth factor under mechanical stimulation conditions. MGF could activate satellite cells, promote the proliferation of osteoblast and inhibit their terminal differentiation. Primary studies show that MGF mainly localize in the nuclear and IGF-IR did not mediate the action of MGF. Till now,the receptor, target and mechanism of MGF signaling is not very clear. In present, we summaried the relationship between MGF and mechanical regulaiton of bone.