甲皱微循环状态可变性的药物干预试验研究

本文用复方丹参、维脑路通、潘生丁三种常用药物进行了药物干预试验,以观察药物性干预能否改变微循环退变。将五十岁以上健康老人三十五名分为三组,分别服用以上三种药物一个月,观察用药前后甲皱微循环十六项指标。结果表明,三个药剂组用药前后有十一项指标,达到差异显著意义水平(P<0.05),表现为输出枝管径增粗、血流增加(潘生丁组);渗出减轻、血栓减少(维脑路通组);管袢数和血色增加、红细胞聚集减少(复方丹参组)。但值得注意的是有两项指标恶化,输出枝及袢顶管径变细,均出现在复方丹参组,值得进一步观察。

The medicine intervention trial study on variability of nailfold microcirculation state

The medicine intervention trial was carried out by using three drugs(Dansen, Venoiruton and Persantin) to observe their effect on decay of microcirculation. 35 health people over 50 years old were separated into three groups and the three agents were taken orally for a month in these groups,respectively. 16 parameters of nailfold microcirculation were detected before and after taking drug. The results suggested that there were significant changes in 11 targets after trial and it was of benefit to the blood flow in microcirculation. But 2 targets turned to worse in Dansen group, these phenomena are merited our attention.