不同时期应用吲哚美辛栓预防ERCP术后胰腺炎及高淀粉酶血症的效果

目的探讨不同时期应用吲哚美辛栓预防内镜逆行胰胆管造影(ERCP)术后胰腺炎及高淀粉酶血症的效果。方法选取本院收治的192例拟行ERCP治疗的胆胰疾病患者作为研究对象,将患者按照随机数字表法分为研究组与对照组,各96例。研究组患者于ERCP术前30 min给予吲哚美辛栓100 mg纳肛处理,对照组患者于ERCP术后2 h给予吲哚美辛栓100 mg纳肛处理。比较两组术前与术后6、24 h血清淀粉酶水平,同时记录两组术后高淀粉酶血症及胰腺炎发生情况。结果术后6、24 h,两组患者血清淀粉酶水平均显著升高,且两组患者术后6 h血清淀粉酶水平明显低于术后24 h(P<0.05);术后6、24 h,研究组患者血清淀粉酶水平明显低于对照组(P<0.05)。研究组患者高淀粉酶血症及胰腺炎的发生率均明显低于对照组(P<0.05)。结论术前30 min给予吲哚美辛栓可以有效降低ERCP术后血清淀粉酶水平,预防术后胰腺炎和高淀粉酶血症的发生。

Effect of application of indomethacin suppository in different stages on the prevention of pancreatitis and hyperamylasemia after ERCP

Objective To investigate the effect of application of indomethacin suppository in different stages on the prevention of pancreatitis and hyperamylasemia after endoscopic retrograde cholangiopancreatography(ERCP). Methods A total of 192 patients with biliary and pancreatic diseases scheduled for ERCP treatment in our hospital were selected as the research objects. The patients were divided into study group and control group according to random number table method, with 96 cases in each group. The study group was treated with indomethacin suppository 100 mg anal intubation30 minutes before ERCP, while the control group was treated with indomethacin suppository 100 mg anal intubation 2 hours after ERCP. The levels of serum amylase before operation and at 6 and 24 hours after operation were compared between the two groups, and the incidences of hyperamylasemia and pancreatitis in both groups were recorded. Results At 6 and 24 hours after operation, the levels of serum amylase in the two groups significantly increased, and the levels of serum amylase in the two groups at 6 hours after operation were significantly lower than those at 24 hours after operation(P<0.05). At 6 and 24 hours after operation, the levels of serum amylase in the study group were significantly lower than those in the control group(P <0.05). The incidences of hyperamylasemia and pancreatitis in the study group were significantly lower than those in the control group(P <0.05). Conclusion Given indomethacin suppository 30 minutes before operation can effectively reduce the level of serum amylase and prevent incidences of pancreatitis and hyperamylasemia after ERCP.