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Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Authors:	Bing Tian Koa Hosoki Zhiqing Liu Jun Yang Yingxin Zhao Hong Sun Jia Zhou Erik Rytting Lata Kaphalia William J Calhoun Sanjiv Sur Allan R Brasier

Affiliation:	1. Department of Internal Medicine, University of Texas Medical Branch, Galveston, Tex;2. Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Tex;3. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Tex;4. Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Tex;5. Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Tex;6. Institute for Clinical and Translational Research, University of Wisconsin–Madison School of Medicine and Public Health, Madison, Wis

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Keywords:	Bromodomain-containing protein 4 epigenetics myofibroblast airway remodeling aeroallergen nuclear factor κB histone acetyltransferase activity BALF Bronchoalveolar lavage fluid BD Bromodomain BMS BMS-345541 BRD4 Bromodomain-containing protein 4 CDE Cat dander extract COL1A Collagen type 1 α1 DAPI 4′-6-Diamidino-2-phenylindole dihydrochloride ECM Extracellular matrix EMT Epithelial mesenchymal transition FN1 Fibronectin HAT Histone acetyltransferase H3K122Ac Acetylated histone H3 on Lys 122 hSAEC Human small airway epithelial cell IFCM Immunofluorescence confocal microscopy IKK IκB kinase IKKi IKK inhibitor MMP Matrix metalloproteinase MS Mass spectrometry NF-κB Nuclear factor κB PAS Periodic acid–Schiff PLA Proximity ligation assay qRT-PCR Quantitative RT-PCR rCDE Repetitive cat dander extract RNA Pol II RNA polymerase II ROS Reactive oxygen species α-SMA α-Smooth muscle actin shRNA Short hairpin RNA SRM Selected reaction monitoring TLR Toll-like receptor UTMB University of Texas Medical Branch VIM Vimentin WT Wild-type
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