化疗有效后内分泌维持治疗晚期乳腺癌八例临床分析

 【摘要】　目的　观察复发转移性乳腺癌化疗缓解后序贯内分泌治疗的疗效。方法　8例复发转移性乳腺癌患者先根据既往用药给予化疗，疾病缓解后采用单药内分泌维持治疗。结果　8例患者接受 2～8个（中位4个）周期化疗，最佳疗效均达部分缓解，治疗持续时间为1～6个月（中位2个月），化疗中位治疗失败时间为4个月。随访至2010年12月31日，8例患者的疾病进展时间为 6～86个月（中位为13.5个月）。中位生存期21.5个月（6～86个月）。7例患者分别因严重的骨髓毒性、乏力或消化道反应而终止化疗，1例因紫杉醇变态反应停止化疗。结论　复发转移性乳腺癌经化疗疾病缓解后，采用内分泌维持治疗可改善患者生活质量，延长有效治疗时间。

Clinical analysis of maintenance hormonal treatment for patients with advanced breast cancer after response to chemotherapy

Objective To observe the efficacy of maintenance hormonal treatment after response to chemotherapy in advanced breast cancer. Methods 8 patients with advanced breast cancer were treated with chemotherapy, maintenance hormonal therapy were given after response to chemotherapy. The efficacy was evaluated every 2 cycles of chemotherapy and 2 months of endocrine therapy according to RECIST standard.Results 8 patients received chemotherapy for 2-8 cycles (median 4 cycles). All patients got PR, the duration of chemotherapy was 1-6 months (median 2 months), the time to failure of chemotherapy was 4 months. Until the last follow-up day (31th December 2010), the time to progression was 6-86 months (median 13.5 months).Survival was 6-86 months (median 21.5 months). Seven patients quit the chemotherapy due to severe side effects of hematologic toxicity, fatigue or nausea vomiting. One patient died because of allergy to paclitaxol.Conclusion Maintenance hormonal treatment after patients with metastatic breast cancer response to chemotherapy may prolong the duration of effective therapy and improve the QOL.