依达拉奉联合醒脑静注射液治疗急性脑出血49例临床疗效分析

目的探讨依达拉奉联合醒脑静注射液治疗老年急性脑出血的临床疗效及对炎性因子的影响。方法将符合脑出血诊断标准的98例老年患者随机分成观察组和对照组各49例,对照组在常规治疗基础上给予依达拉奉,观察组在对照组基础上辅助给予醒脑静治疗。2组疗程均为14 d,观察2组患者的神经功能缺损(NIHSS)、蒙特利尔认知评估(MoCA)、日常生活活动能力(ADL)评分,检测TNF-α、IL-1、IL-6等炎性因子水平,并比较临床疗效。结果与治疗前比较,2组患者治疗后NIHSS、MoCA以及ADL评分均明显改善(P<0.05),且观察组评分明显优于对照组(P<0.05);与治疗前比较,2组治疗后血浆炎性因子TNF-α、IL一1和IL-6水平均显著降低(P<0.05),且观察组治疗后第7、14天较对照组明显降低(P<0.05)。观察组痊愈率、总有效率分别为53.1%、95.9%,均显著高于对照组的28.6%和75.5%,差异有统计学意义(P<0.05)。结论依达拉奉联合醒脑静注射液治疗老年急性脑出血疗效肯定,值得临床推广。

Observation of edaravone and Xingnaojing injection in treatment of patients with acute intra-cerebral hemorrhage

Objective To investigate the clinical efficacy of edaravone combined with Xingnaojing injection in the treatment of senile acute cerebral hemorrhage and its effect on inflammatory factors.Methods According to standard diagnosis of cerebral hemorrhage,98 cases of elderly patients were randomly divided into observation group and control group with 49 cases in each group,the control group on the basis of conventional therapy,given edaravone,the observation group were given edaravone,Xingnaojing injection treatment.The 2 groups were treated for 14 d,neurologic function deficit score（NIHSS）,the Montreal cognitive assessment（MoCA）,activities of daily living（ADL） score of the 2 groups were assessed,the detection of levels of inflammatory factors of TNF-alpha,IL-1,IL-6 were recorded,and observed the clinical curative effect.Results Compared with those of before treatment,after treatment 2 groups＇ NIHSS,MoCA and ADL score were significantly improved（P〈0.05）,the observation group was significantly better than the control group（P〈0.05）;compared with before treatment,after treatment 2 groups＇ plasma levels of inflammatory factor were significantly reduced（P 〈0.05）,and the observation group 7 daus.14 days after treatment were significantly lower than the control group（P〈0.05）.In observation group,the cure rate was 53.1%,the total efficiency was 95.9%,significantly higher than those of control group of 28.6%and 75.5%,the difference was statistically significant（P〈 0.05）.Conclusion Edaravone combined with Xingnaojing injection in the treatment of elderly patients with acute intra-cerebral hemorrhage,and it is worth for clinical promotion.