| 八厘麻毒素对兔心室不应期的影响 |
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| 引用本文： | 邱汉婴 李迪俊. 八厘麻毒素对兔心室不应期的影响[J]. 中国药理学通报, 1997, 13(3): 247-248 |
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| 作者姓名： | 邱汉婴 李迪俊 |
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| 作者单位： | 汕头大学医学院第二附属医院心血管病研究室 |
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| 摘 要： | 目的：研究八厘麻毒素对兔心室不应期的影响。方法：使用心室壁插入电极，观察并记录八厘麻毒素（Ｒｈ）１２．５μｇ·ｋｇ－１或２５μｇ·ｋｇ－１ｉｖ（用药后不同时间）对兔心室电生理参数的影响。结果：在Ｒｈ１２．５μｇ·ｋｇ－１ｉｖ后２０、４０、６０和８０ｍｉｎ，ＶＤＴ、ＥＲＰ和ＲＲＰ均无显著变化；而Ｒｈ２５μｇ·ｋｇ－１ｉｖ，在用药后的同样时间内可见ＥＲＰ和ＲＲＰ显著延长（Ｐ＜０．０５）。结论：Ｒｈ具有延长兔心室不应期的作用。
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| 关 键 词： | 八厘麻毒素；兔；心室不应期 |
Effects of rhomotoxin on ventricular refractory period in the rabbit heart |
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| QIU Han Ying,LI Di Jun,MAO Huan Yuan. Effects of rhomotoxin on ventricular refractory period in the rabbit heart[J]. Chinese Pharmacological Bulletin, 1997, 13(3): 247-248 |
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| Authors: | QIU Han Ying LI Di Jun MAO Huan Yuan |
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| Affiliation: | QIU Han Ying,LI Di Jun,MAO Huan Yuan 1 |
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| Abstract: | AIM:Effect of rhomotoxin (Rh) 12 5 μg·kg -1 or 25 μg·kg -1 iv on ventricular refractory period was observed. METHOD:Using ventricular plunge electrode. RESULTS:At 20, 40, 60 and 80 min (after Rh 12 5 μg·kg -1 iv); VDT, ERP and RRP had no significant changes; but at 20, 40, 60 and 80 min, Rh 25 μg·kg -1 iv caused significant prolongation of ERP and (or) RRP ( P <0 05). CONCLUSIONS :That Rh wight have effect of prolongating ventricular refractory period. |
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| Keywords: | rhomotoxin (Rh) rabbit ventricular refractory period |
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