锌诱导的金属硫蛋白在大鼠高血压发病中的保护作用

目的：观察金属硫蛋白（ｍｅｔａｌｏｔｈｉｏｎｅｉｎ，ＭＴ）对高血压发病的防治作用。方法：采用腹主动脉狭窄－高盐摄入性高血压模型，事先给予氯化锌诱导内源性金属硫蛋白，观察心肌组织的ＭＴ和丙二醛（ＭＤＡ）的水平以及血压的变化。结果：心脏及肾脏组织的ＭＴ水平在锌诱导组较高血压组各增加１．７倍（Ｐ＜０．０１）及２．４倍（Ｐ＜０．０１），而丙二醛水平则分别下降８０％（（Ｐ＜０．０１）和４４％（Ｐ＜０．０１），锌诱导组的血压较高血压组血压下降２８％（Ｐ＜０．０５），并且观察到心肌ＭＴ水平与ＭＤＡ含量呈明显负相关（ｒ＝－０．９５，Ｐ＜０．０１）。结论：ＭＴ清除自由基作用可能在高血压发病中具有一定的保护意义。

Protective effects of Zn induced metallothionein on myocardial injury of hypertensive rats

AIM: To examine protective roles of metallothionein(MT) on hypertensive rats. METHODS: By the model of hypertensive rats of abdominal constrition high salt diet, endogenetic MT was induced by pre administered ZnCl 2, the levels of MT and MDA were measured in myocardial and renal tissues, and the levels of blood pressure were examined in treated groups. RESULTS: The MT levels of myocardial and renal tissues in Zn induced group increased 1 7 times ( P<0 01 ) and 2 4 times ( P<0 01 ) of hypertensive group, the MDA levels of myocardial and renal tissues decreased 80% ( P<0 01 ) and 44% ( P<0 01 ), the level of blood pressure in Zn induced group reduced 28% ( P< 0 05) of the blood pressure in hypertensive group, the content of cardiac MT has obviously negative relation with the level of cardiac MDA ( r=-0 95,P<0 01 ). CONCLUSION: Protective effects of MT in hypertensive rats may be related to scavenging free radicals.