Risk Assessment for Aflatoxin: An Evaluation Based on the Multistage Model |
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| Authors: | J Bowers B Brown J Springer L Tollefson R Lorentzen S Henry |
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| Affiliation: | U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street, S.W., Washington, D.C. 20204. |
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| Abstract: | Lifetime cancer potency of alfatoxin was assessed based on the Yeh et al. study from China in which both aflatoxin exposure and hepatitis B prevalence were measured. This study provides the best available information for estimating the carcinogenic risk posed by aflatoxin to the U.S. population. Cancer potency of aflatoxin was estimated using a biologically motivated risk assessment model. The best estimate of aflatoxin potency was 9 (mg/kg/day)−1 for individuals negative for hepatitis B and 230 (mg/kg/day)−1 for individuals positive for hepatitis B. |
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| Keywords: | Aflatoxin risk assessment cancer potency multistage models |
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